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Developing a new chordate model for stem cell biology and regeneration

Award Number: R21OD030520
ORGANIZATION: OFFICE OF THE DIRECTOR, NIH
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 03/15/2022
PERIOD OF PERFORMANCE END DATE: 02/28/2026

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Developing a new chordate model for stem cell biology and regeneration - ABSTRACT The goal of this grant is to adapt contemporary single cell resolution and genomic manipulation tools to utilize the unique regenerative biology of the colonial ascidian species, Botryllus schlosseri. The FOA we are responding to from ORIP has as its stated goal to create new and innovative models for stem cell biology and regeneration, and Botryllus has a proven track record of innovative studies and a wealth of biology that will be made accessible with these new tools. Ascidians are chordates, and considered to be the closest living relatives to the vertebrates. Species such as Ciona have become powerful models in dissecting early steps in chordate embryogenesis due to their relative simplicity and rapid development, and share many chordate-specific features, including early mechanisms underlying cell specification, as well as clonal origins of multiple tissues. In addition to this close phylogenetic relationship, a subset of ascidian species are colonial, and grow, not by increasing in size, but via a process of regeneration- whereby entire bodies- including all cardiovascular, nervous, endocrine and germline tissues- are regenerated, and in Botryllus this occurs every week in a synchronized fashion, providing a novel model to study regeneration of all major organ systems in a chordate. Colonial ascidians are the only chordates with the ability to regenerate every tissue and organ in their body and unique life history characteristics make Botryllus a potentially outstanding model for these studies.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $0 )
2025	2023	UNIVERSITY OF CALIFORNIA, SANTA BARBARA	3227 CHEADLE HALL	SANTA BARBARA	CA	93106	SANTA BARBARA	USA	Research Infrastructure Programs	000	2	3/14/2025	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2023 ( Subtotal = $222,219 )
2023	2023	UNIVERSITY OF CALIFORNIA, SANTA BARBARA	3227 CHEADLE HALL	SANTA BARBARA	CA	93106	SANTA BARBARA	USA	Research Infrastructure Programs	000	2	2/17/2023	NON-COMPETING CONTINUATION	$222,219
														Subtotal = $222,219

Issue Date FY: 2022 ( Subtotal = $183,927 )
2022	2022	UNIVERSITY OF CALIFORNIA, SANTA BARBARA	3227 CHEADLE HALL	SANTA BARBARA	CA	93106	SANTA BARBARA	USA	Research Infrastructure Programs	001	1	5/7/2022	NEW	$18,392
2022	2022	UNIVERSITY OF CALIFORNIA, SANTA BARBARA	3227 CHEADLE HALL	SANTA BARBARA	CA	93106	SANTA BARBARA	USA	Research Infrastructure Programs	000	1	2/25/2022	NEW	$165,535
														Subtotal = $183,927

Grand Total All Awards = $406,146

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Developing a new chordate model for stem cell biology and regeneration

Award Number: R21OD030520

ORGANIZATION: OFFICE OF THE DIRECTOR, NIH

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 03/15/2022

PERIOD OF PERFORMANCE END DATE: 02/28/2026

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