Wednesday, December 31, 2025 12/31/2025

Exploratory Analysis Tools for Developmental Studies of Brain Microstructure with Diffusion MRI

Award Number: R21MH132982
ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 06/23/2023
PERIOD OF PERFORMANCE END DATE: 05/31/2026

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Exploratory Analysis Tools for Developmental Studies of Brain Microstructure with Diffusion MRI - Project Summary Diffusion MRI analysis is the primary tool for studying brain white matter microstructure. Adolescent brain development involves significant microstructural changes due to brain reorganization and neural pruning. The trajectory of these changes can be altered by the onset of mental disorders, and longitudinal analysis of diffusion imaging is needed to capture these alterations. Our proposal aims to make available an open source software platform for exploratory analysis of longitudinal diffusion MRI datasets, and to apply it to study the early onset of bipolar disorder in the Adolescent Brain Cognitive Development (ABCD) data. Diffusion tensor imaging is not sufficient to distinguish the different types of changes that occur during adolescent brain development, so our software tool will support more advanced diffusion models such as Neurite Orientation Dispersion and Density Imaging. This takes advantage of the high angular resolution of ABCD diffusion images. The exploratory tools we develop will employ the widely used Tract-Based Spatial Statistics (TBSS) technique, which is a dimensionality reduction that is well suited for exploratory analysis. Going beyond standard TBSS, we will adapt the technique to work with improved registration techniques, to work with more advanced diffusion models, and to provide developmental trajectories based on longitudinal imaging data. The TBSS methodology requires high quality image alignment. In order to achieve this, we will develop a deep learning model for pairwise registration of diffusion datasets, speeding up an important step in diffusion MRI analysis. By generating fiber orientation distributions from the ABCD diffusion imaging, our registration model will align fiber orientations in addition to anatomical structures. These tools will be made available in an open source software platform. While there are many tools for exploring diffusion MRI data, this one will be unique in its support for longitudinal datasets with high angular resolution imaging.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $0 )
2025	2024	KITWARE INC	1712 ROUTE 9	HALFMOON	NY	12065	SARATOGA	USA	Mental Health Research Grants	000	2	3/21/2025	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2024 ( Subtotal = $314,054 )
2024	2024	KITWARE INC	1712 ROUTE 9	HALFMOON	NY	12065	SARATOGA	USA	Mental Health Research Grants	000	2	6/21/2024	NON-COMPETING CONTINUATION	$314,054
														Subtotal = $314,054

Issue Date FY: 2023 ( Subtotal = $252,227 )
2023	2023	KITWARE INC	1712 ROUTE 9	CLIFTON PARK	NY	12065	SARATOGA	USA	Mental Health Research Grants	000	1	6/23/2023	NEW	$252,227
														Subtotal = $252,227

Grand Total All Awards = $566,281

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Exploratory Analysis Tools for Developmental Studies of Brain Microstructure with Diffusion MRI

Award Number: R21MH132982

ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 06/23/2023

PERIOD OF PERFORMANCE END DATE: 05/31/2026

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