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Dynamic Regulatory Processes in the Transition from Suicidal Ideation to Action: The Roles of Cognitive Control, Emotion-Related Impulsivity, and Sleep in the Context of Negative Affective Experiences

Award Number: R21MH124794
ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 12/01/2020
PERIOD OF PERFORMANCE END DATE: 10/31/2024

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Dynamic Regulatory Processes in the Transition from Suicidal Ideation to Action: The Roles of Cognitive Control, Emotion-Related Impulsivity, and Sleep in the Context of Negative Affective Experiences - Project Abstract Few NIMH-funded studies have examined contributors to short-term, within-person changes in suicidal ideation and odds of suicidal behavior. We propose to use multi-modal assessments (self-report, behavior, actigraphy) to capture changes in several RDoC domains relevant to suicide risk. In an ideation-to-action framework, we differentiate acute risk factors for suicidal thoughts from those that contribute to the transition from suicidal ideation to behavior. We will test our theoretical model using a 28-day intensive longitudinal design in a sample of suicidal adults leaving inpatient behavioral health care, a population at particularly high risk for suicide. Aim 1: Examine a set of transtheoretical risk factors as proximal predictors of within-person changes in suicidal thoughts. Using ecological momentary assessment, we will gather repeated measures of seven hypothesized ideation risk factors, as well as a dimensional measure of ideation, to model lagged relationships between affective risk factors and subsequent ideation. We expect that each affective risk factor will show a positive association with subsequent increases in suicidal ideation, and that these risk factors will co-occur in daily life such that they are best conceptualized as a single latent construct capturing emotional suffering (psychache). Aim 2: Test self-report and behavioral measures of inhibitory control as risk factors for suicidal behavior. We expect that participants who, at baseline, report greater emotion-related impulsivity, and who show impaired response inhibition in a behavioral task using negative valence stimuli, will have higher odds of suicide attempt over follow-up. Using a novel mobile adaptation of an inhibitory control task during the ecological momentary assessment period, we expect that within-person decrements in inhibitory control will precede within-person increases in likelihood of suicide attempt among individuals thinking of suicide. Aim 3: Evaluate objectively measured sleep duration as a proximal risk factor for both suicidal ideation and suicidal behavior. Using wrist-worn actigraphy devices, we will examine how short sleep duration, compared to participants’ average sleep, relates to next-day ideation and attempts. We expect that short sleep duration will predict within-person increases in suicidal thoughts, as well as increased likelihood of suicide attempts, controlling for suicidal ideation. Finally, we will test an exploratory hypothesis, that the sleep-suicide attempt association is explained by sleep-related decreases in inhibitory control in the context of negative affect. Findings from this study will elucidate modifiable affective, cognitive, and physiological targets for just-in-time, mobile interventions to prevent suicide.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $0 )
2025	2022	TEXAS TECH UNIVERSITY SYSTEM	2500 BROADWAY	LUBBOCK	TX	79409	LUBBOCK	USA	Mental Health Research Grants	000	2	3/25/2025	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2024 ( Subtotal = $0 )
2024	2022	TEXAS TECH UNIVERSITY SYSTEM	2500 BROADWAY	LUBBOCK	TX	79409	LUBBOCK	USA	Mental Health Research Grants	000	2	10/17/2023	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2022 ( Subtotal = $258,810 )
2022	2022	TEXAS TECH UNIVERSITY SYSTEM	2500 BROADWAY	LUBBOCK	TX	79409	LUBBOCK	USA	Mental Health Research Grants	000	2	10/25/2021	NON-COMPETING CONTINUATION	$169,103
2022	2022	TEXAS TECH UNIVERSITY SYSTEM	2500 BROADWAY	LUBBOCK	TX	79409	LUBBOCK	USA	Mental Health Research Grants	002	2	6/21/2022	NON-COMPETING CONTINUATION	$18,790
2022	2022	TEXAS TECH UNIVERSITY SYSTEM	2500 BROADWAY	LUBBOCK	TX	79409	LUBBOCK	USA	Mental Health Research Grants	001	2	4/19/2022	SUPPLEMENT FOR EXPANSION	$70,917
														Subtotal = $258,810

Issue Date FY: 2021 ( Subtotal = $236,997 )
2021	2021	TEXAS TECH UNIVERSITY SYSTEM	2500 BROADWAY	LUBBOCK	TX	79409	LUBBOCK	USA	Mental Health Research Grants	000	1	11/24/2020	NEW	$236,997
2021	2021	TEXAS TECH UNIVERSITY SYSTEM	2500 BROADWAY	LUBBOCK	TX	79409	LUBBOCK	USA	Mental Health Research Grants	001	1	2/16/2021	NEW	$0
														Subtotal = $236,997

Grand Total All Awards = $495,807

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Dynamic Regulatory Processes in the Transition from Suicidal Ideation to Action: The Roles of Cognitive Control, Emotion-Related Impulsivity, and Sleep in the Context of Negative Affective Experiences

Award Number: R21MH124794

ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 12/01/2020

PERIOD OF PERFORMANCE END DATE: 10/31/2024

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