Friday, March 14, 2025
3/14/2025
Schizophrenia (Sz) is a severe psychiatric disorder associated with core neurocognitive deficits. Although, traditional models of schizophrenia focus on dysfunction within cognitive and sensory processing cortical regions, increasing evidence has accumulated suggestive of subcortical processing impairments as well. Deficits along the subcortical visual pathways, especially involving the magnocellular visual pathway, have been tied to deficits in the generation of early cortical responses which, in turn, contribute to higher-order cortical impairments. These deficits, however, may not account for all visual information processing abnormalities in Sz. Recently, we have observed deficits in the modulation of ongoing scalp- recorded alpha activity, which appear independent of the traditional magno/parvocellular pathways, and which may be mediated by dysfunction of the “retinotectal” visual pathway, which involves the superior colliculus (SC) and the pulvinar nucleus of the thalamus (PuN), but which bypasses the lateral geniculate nucleus (LGN). At present, tools for the evaluation of the retinotectal system within neuropsychiatric populations remain limited. In this project we will conduct a side-by-side comparison of potential paradigms gleaned from the basic science literature to elicit PuN/SC activation and will study their feasibility and psychometric properties. These paradigms will then be used to assess the integrity of PuN/SC processing in Sz relative to alpha generation and cognitive performance.
HHS’ Tracking Accountability in Government Grants System (TAGGS) website provides access to detailed descriptions of grants, loans, aggregated direct payments and other types of financial assistance awarded by the HHS Operating Divisions (OPDIVs) and the Office of the Secretary Staff Divisions (STAFFDIVs).