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REM AND NREM PROCESSING SPECIALIZATIONS

Award Number: R21MH076916
ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/20/2007
PERIOD OF PERFORMANCE END DATE: 07/31/2009

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REM AND NREM PROCESSING SPECIALIZATIONS - DESCRIPTION (provided by applicant): The purpose of this R21 proposal is to develop a new research program that will explore potential cognitive processing specializations of REM (rapid eye movement) and NREM (non-REM) sleep states. Identifying such processing specializations would point to hitherto unrecognized correlates of functional specializations for REM and NREM and thus may lead to a breakthrough in our understanding of sleep function. In a recent (McNamara, McLaren, Smith, Brown, & Stickgold, 2005) analysis of over 500 mentation reports from the REM, NREM and wake states, we found that REM exhibited greater numbers of simulations of aggressive social interactions than NREM or waking reports, and NREM exhibited greater numbers of simulations of friendly interactions than REM or wake reports. Indeed, there were absolutely no (zero) simulations of aggressive interactions in NREM reports. We plan to follow-up on and extend these findings by performing overnight polysomnographic recordings along with REM and NREM awakenings in a group of healthy young volunteers. We will explore the following questions in the proposed experiments: 1) Can the McNamara et al. (2005) findings be replicated and extended? Is there any evidence for REM and NREM cognitive processing specializations with respect to a) simulations of social interactions, b) emotions, and c) attributions of intentional states to other dream characters ("Theory of Mind") and 2) Is content of a NREM "dream" related to the content of a REM "dream" across a single night of sleep? Identifying cognitive processing specializations of REM and NREM sleep will yield better quantitative models of a variety of sleep disorders and better treatment of sleep-related mental health disorders. Public Health Relevance: This Public Health Relevance is not available.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2008 ( Subtotal = $203,125 )
2008	2008	BOSTON UNIVERSITY	25 BUICK STREET	BOSTON	MA	02215	SUFFOLK	USA	Mental Health Research Grants	000	2	8/20/2008	NON-COMPETING CONTINUATION	$203,125
														Subtotal = $203,125

Issue Date FY: 2007 ( Subtotal = $189,000 )
2007	2007	BOSTON UNIVERSITY	25 BUICK STREET	BOSTON	MA	02215	SUFFOLK	USA	Mental Health Research Grants	000	1	9/20/2007	NEW	$189,000
														Subtotal = $189,000

Grand Total All Awards = $392,125

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REM AND NREM PROCESSING SPECIALIZATIONS

Award Number: R21MH076916

ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/20/2007

PERIOD OF PERFORMANCE END DATE: 07/31/2009

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