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Acculturative stress and pro-inflammatory markers among Mexican-Origin adults with NAFLD

Award Number: R21MD019331
ORGANIZATION: NATIONAL CENTER ON MINORITY HEALTH AND HEALTH DISPARITIES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/15/2024
PERIOD OF PERFORMANCE END DATE: 03/31/2027

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Acculturative stress and pro-inflammatory markers among Mexican-Origin adults with NAFLD - ABSTRACT Non-alcoholic fatty liver disease (NAFLD), an emerging risk factor for hepatocellular carcinoma (HCC), disproportionately impacts the Mexican-origin (MO) population. This is of particular concern as liver disease and liver cancer are among the leading causes of death for MO adults. While disparities of NAFLD prevalence have been attributed to the interplay of genetic, behavioral, and socioenvironmental factors, limited scientific efforts have been undertaken to characterize the underlying mechanisms driving the well documented NAFLD disparities in MO communities. Further, despite MO adults increased risk of experiencing acculturative stress, it has rarely been considered in the context of NAFLD. This is a significant gap in knowledge given acculturative stress has been linked to poor lifestyle behaviors (e.g., diet) and stress-related inflammation; thereby driving aberrant liver pathologies and ultimately cancer carcinogenesis. In fact, it has been hypothesized that elevated levels of pro-inflammatory markers may be the primary pathophysiological pathway linking acculturative stress and NAFLD. However, this remains to be determined. Thus, the proposed project will combine complementary quantitative and qualitative approaches in a mixed-methods project to (1) investigate the relationship between acculturative stress and NAFLD severity among a sample of 150 MO adults with known NAFLD; (2) the relationship between acculturative stress and pro-inflammatory markers among a sample of 150 MO adults with known NAFLD; and (3) qualitatively assess the impact of acculturative stress on MO adults’ modifiable behaviors that drive inflammatory response and are central to NAFLD management. The proposed project, led by an experienced multidisciplinary team of investigators, is a critical step to develop effective stress management strategies to reduce NAFLD and liver cancer risk among MO individuals.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $0 )
2026	2025	UNIVERSITY OF ARIZONA	845 N PARK AVE RM 538	TUCSON	AZ	85721	PIMA	USA	Minority Health and Health Disparities Research	000	2	1/23/2026	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2025 ( Subtotal = $191,875 )
2025	2025	UNIVERSITY OF ARIZONA	845 N PARK AVE RM 538	TUCSON	AZ	85721	PIMA	USA	Minority Health and Health Disparities Research	002	2	6/14/2025	NON-COMPETING CONTINUATION	$191,875
2025	2024	UNIVERSITY OF ARIZONA	845 N PARK AVE RM 538	TUCSON	AZ	85721	PIMA	USA	Minority Health and Health Disparities Research	000	1	11/4/2024	NEW	$0
2025	2024	UNIVERSITY OF ARIZONA	845 N PARK AVE RM 538	TUCSON	AZ	85721	PIMA	USA	Minority Health and Health Disparities Research	001	1	3/17/2025	NEW	$0
														Subtotal = $191,875

Issue Date FY: 2024 ( Subtotal = $230,250 )
2024	2024	UNIVERSITY OF ARIZONA	845 N PARK AVE RM 538	TUCSON	AZ	85721	PIMA	USA	Minority Health and Health Disparities Research	000	1	9/15/2024	NEW	$230,250
2024	2024	UNIVERSITY OF ARIZONA	845 N PARK AVE RM 538	TUCSON	AZ	85721	PIMA	USA	Minority Health and Health Disparities Research	001	1	9/16/2024	NEW	$0
														Subtotal = $230,250

Grand Total All Awards = $422,125

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Acculturative stress and pro-inflammatory markers among Mexican-Origin adults with NAFLD

Award Number: R21MD019331

ORGANIZATION: NATIONAL CENTER ON MINORITY HEALTH AND HEALTH DISPARITIES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/15/2024

PERIOD OF PERFORMANCE END DATE: 03/31/2027

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