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SMILE-PD: Similarity Matching In Longitudinal Electronic Patient Data

Award Number: R21LM014454
ORGANIZATION: NATIONAL LIBRARY OF MEDICINE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/06/2023
PERIOD OF PERFORMANCE END DATE: 11/30/2025

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SMILE-PD: Similarity Matching In Longitudinal Electronic Patient Data - PROJECT SUMMARY The NIH All of Us (AoU) Research Program is a national research initiative launched by the National Institutes of Health (NIH) in May 2018 with the goal of advancing precision medicine, which aims to provide personalized medical treatment and prevention strategies based on an individual's unique genetic, environmental, and lifestyle factors. Analysis of real world data like AoU typically requires creation of cohorts that are clinically similar with the exception of the characteristic(s) being evaluated. If the creation of compared cohorts is not conducted with care, results may be confounded by systematic difference in the characteristics of patients assigned to the compared cohorts. This proposal, Similarity Matching In Longitudinal Electronic Patient Data (SMILE PD), will apply a sophisticated patient matching algorithm within an easy- to-use interface to help Investigators to create suitable analytical cohorts to enable generation of accurate, reproducible real world evidence from the rich content of the All of Us data. The project has 4 Aims : • Aim 1. Develop algorithms that learn patient similarities from AoU data in a comprehensive manner. • Aim 2: Develop approaches that can integrate drug and disease information from publicly available data sources to improve the quality of learned patient similarities. • Aim 3: Implement an interactive user interface to specify similarity matching criteria and demonstrate the learned patient similarities • Aim 4 : Apply the patient similarity matching algorithm and interface to conduct an initial assessment of the impact of mental illness and its treatment on chronic disease outcomes The patient similarity matching interface created through this proposal will enable investigators to conduct predictive analytics, risk assessments and comparative effectiveness research in a more robust and reproducible fashion.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $0 )
2026	2024	WEILL MEDICAL COLLEGE OF CORNELL UNIVERSITY	575 LEXINGTON AVE FL 9	NEW YORK	NY	10022	NEW YORK	USA	Medical Library Assistance	000	2	11/26/2025	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2025 ( Subtotal = $0 )
2025	2024	WEILL MEDICAL COLLEGE OF CORNELL UNIVERSITY	575 LEXINGTON AVE FL 9	NEW YORK	NY	10022	NEW YORK	USA	Medical Library Assistance	000	2	7/10/2025	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2024 ( Subtotal = $228,825 )
2024	2024	WEILL MEDICAL COLLEGE OF CORNELL UNIVERSITY	575 LEXINGTON AVE FL 9	NEW YORK	NY	10022	NEW YORK	USA	Medical Library Assistance	000	2	8/9/2024	NON-COMPETING CONTINUATION	$228,825
														Subtotal = $228,825

Issue Date FY: 2023 ( Subtotal = $190,688 )
2023	2023	WEILL MEDICAL COLLEGE OF CORNELL UNIVERSITY	1300 YORK AVE	NEW YORK	NY	10065	NEW YORK	USA	Medical Library Assistance	000	1	9/6/2023	NEW	$190,688
														Subtotal = $190,688

Grand Total All Awards = $419,513

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SMILE-PD: Similarity Matching In Longitudinal Electronic Patient Data

Award Number: R21LM014454

ORGANIZATION: NATIONAL LIBRARY OF MEDICINE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/06/2023

PERIOD OF PERFORMANCE END DATE: 11/30/2025

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