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Classifying Sepsis Survivors into Actionable Phenotypes

Award Number: R21LM013373
ORGANIZATION: NATIONAL LIBRARY OF MEDICINE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 05/01/2020
PERIOD OF PERFORMANCE END DATE: 04/30/2023

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Classifying Sepsis Survivors into Actionable Phenotypes - PROJECT SUMMARY Sepsis survivors face myriad challenges in the post-sepsis recovery period. Both sepsis survivors and healthcare systems are motivated to reduce the strikingly high rate of hospital readmission following an initial hospitalization for sepsis. Unfortunately, current one-size-fits-all approaches to risk prediction and treatment strategies are inadequate for optimizing care for this heterogenous population. The overarching goal of our work is to improve health outcomes and reduce healthcare utilization for sepsis survivors. The objectives of this study are to apply latent class analysis (LCA) to identify important new phenotypes of sepsis survivors with distinct characteristics and risk profiles, and to demonstrate the application of LCA in determining whether phenotype membership moderates the effectiveness of interventions designed to reduce readmission. To achieve this objective we will 1) use our team's large, feature-rich sepsis datamart to identify distinct phenotypes of sepsis survivors based on patients' predisposing characteristics, illness factors, and treatments, 2) validate the predictive utility of the developed method in a separate sample of 1200 sepsis survivors, and 3) determine whether phenotype is a moderator of the effectiveness of a sepsis recovery program currently being tested by our team in a clinical trial. Sepsis survivors represent a vulnerable population with high morbidity, mortality, and hospital readmissions, and strategies to improve transition and recovery are urgently needed. By transitioning away from whether post-sepsis treatment strategies work toward which strategies work best for whom, our project will be the first rigorous examination of phenotypes of sepsis survivors and their association with readmission risk and differential treatment effects. Ultimately, these results will provide clinicians, researchers, and policy makers with immediate, actionable data about how to target interventions to specific group vulnerabilities, leading to effective and efficient reduction in post-sepsis morbidity.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = -$45,358 )
2024	2021	THE CHARLOTTE-MECKLENBURG HOSPITAL AUTHORITY	1000 BLYTHE BLVD	CHARLOTTE	NC	28203	MECKLENBURG	USA	Medical Library Assistance	000	2	11/17/2023	NON-COMPETING CONTINUATION	-$45,358
														Subtotal = -$45,358

Issue Date FY: 2021 ( Subtotal = $168,563 )
2021	2021	CHARLOTTE-MECKLENBURG HOSPITAL AUTHORITY, THE	1000 BLYTHE BOULEVARD	CHARLOTTE	NC	28203	MECKLENBURG	USA	Medical Library Assistance	001	2	4/30/2021	NON-COMPETING CONTINUATION	$8,429
2021	2021	CHARLOTTE-MECKLENBURG HOSPITAL AUTHORITY, THE	1000 BLYTHE BOULEVARD	CHARLOTTE	NC	28203	MECKLENBURG	USA	Medical Library Assistance	000	2	4/13/2021	NON-COMPETING CONTINUATION	$160,134
														Subtotal = $168,563

Issue Date FY: 2020 ( Subtotal = $202,275 )
2020	2020	CHARLOTTE-MECKLENBURG HOSPITAL AUTHORITY, THE	1000 BLYTHE BOULEVARD	CHARLOTTE	NC	28203	MECKLENBURG	USA	Medical Library Assistance	000	1	4/23/2020	NEW	$202,275
														Subtotal = $202,275

Grand Total All Awards = $325,480

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Classifying Sepsis Survivors into Actionable Phenotypes

Award Number: R21LM013373

ORGANIZATION: NATIONAL LIBRARY OF MEDICINE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 05/01/2020

PERIOD OF PERFORMANCE END DATE: 04/30/2023

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