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Developing cardiac organoids with deliberate heterogeneity for modeling sinus node dysfunction

Award Number: R21HL184119
ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 04/01/2026
PERIOD OF PERFORMANCE END DATE: 03/31/2028

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Developing cardiac organoids with deliberate heterogeneity for modeling sinus node dysfunction - ABSTRACT Sinus node dysfunction (SND) is a significant heart rhythm disorder that affects both young patients with congenital heart conditions and adults due to aging or secondary complications from other heart diseases. For symptomatic patients, pacemaker implantation is often required, particularly in children, where it frequently indicates worsening heart function and poor clinical outcomes. Despite its high prevalence, the underlying causes and progression of SND remain poorly understood. A major challenge in advancing treatments is the lack of a reliable human model that effectively replicates the sinoatrial node and its dysfunction. This project aims to address this gap by utilizing human cardiac pacemaker organoids derived from iPSCs to model SND. We hypothesize that integrating nonmyocytes into these organoids plays a crucial role in accurately mimicking the sinoatrial node and the progression of SND. By applying constant or cyclic mechanical strain, we will simulate the disease environment to better understand its mechanisms. These organoids will mirror the cellular diversity of the native sinoatrial node, offering a rigorous platform to explore the etiology of SND. The ultimate goal is to identify key molecular targets that could lead to novel therapies, reducing the need for permanent pacemaker implants and improving patient outcomes.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $232,500 )
2026	2026	THE JOHNS HOPKINS UNIVERSITY	3400 N CHARLES ST	BALTIMORE	MD	21218	BALTIMORE CITY	USA	Cardiovascular Diseases Research	000	1	4/2/2026	NEW	$232,500
														Subtotal = $232,500

Grand Total All Awards = $232,500

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Developing cardiac organoids with deliberate heterogeneity for modeling sinus node dysfunction

Award Number: R21HL184119

ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 04/01/2026

PERIOD OF PERFORMANCE END DATE: 03/31/2028

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