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Retrospective Single Image Multi-endPoint anaLysis (SIMPL) to define pathophysiologic mechanisms of heart failure with preserved ejection fraction.

Award Number: R21HL167171
ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/01/2023
PERIOD OF PERFORMANCE END DATE: 08/31/2026

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Retrospective Single Image Multi-endPoint anaLysis (SIMPL) to define pathophysiologic mechanisms of heart failure with preserved ejection fraction. - Project Summary Heart Failure with Preserved Ejection Fraction (HFpEF) is the most common form of heart failure, is associated with high morbidity and mortality, with increasing prevalence and worsening prognosis. Quality-of-life in HFpEF is as poor or worse than heart failure with reduced ejection fraction, in large part because of severe exercise intolerance; the primary manifestation of this bourgeoning condition. Per funding announcement PAR-20-078 which supports the use of existing human datasets for well-focused secondary analyses to investigate new methods that have the potential for significant impact on NHLBI relevant biomedical or biobehavioral research, we will leverage an existing database of cardiac magnetic resonance images in a cohort of well-phenotyped patients with HFpEF and age- and sex-matched healthy controls to comprehensively identify and characterize pathophysiologic mechanisms driving HFpEF. We will use a novel Single Image Multi-endPoint anaLysis (SIMPL) approach to compare four chamber cardiac function (right atrium, right ventricle, left atrium, left ventricle), aortic distensibility, and pericardial fat burden between HFpEF and healthy controls, and to determine their independent and combined association with exercise tolerance and quality of life.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $0 )
2026	2024	UNIVERSITY OF TEXAS AT ARLINGTON	701 S NEDDERMAN DR	ARLINGTON	TX	76019	TARRANT	USA	Cardiovascular Diseases Research	000	2	3/13/2026	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2024 ( Subtotal = $122,220 )
2024	2024	UNIVERSITY OF TEXAS AT ARLINGTON	701 S NEDDERMAN DR	ARLINGTON	TX	76019	TARRANT	USA	Cardiovascular Diseases Research	000	2	8/24/2024	NON-COMPETING CONTINUATION	$122,220
														Subtotal = $122,220

Issue Date FY: 2023 ( Subtotal = $125,580 )
2023	2023	THE UNIVERSITY OF TEXAS AT ARLINGTON	701 S. NEDDERMAN DR	ARLINGTON	TX	76019	TARRANT	USA	Cardiovascular Diseases Research	000	1	8/25/2023	NEW	$125,580
														Subtotal = $125,580

Grand Total All Awards = $247,800

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Retrospective Single Image Multi-endPoint anaLysis (SIMPL) to define pathophysiologic mechanisms of heart failure with preserved ejection fraction.

Award Number: R21HL167171

ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/01/2023

PERIOD OF PERFORMANCE END DATE: 08/31/2026

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