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Pregnancy complications, future cardiovascular disease risk factors and cardiovas

Award Number: R21HL115398
ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 08/15/2013
PERIOD OF PERFORMANCE END DATE: 04/30/2017

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Pregnancy complications, future cardiovascular disease risk factors and cardiovas - DESCRIPTION (provided by applicant): Currently available cardiovascular (CVD) risk scores in women usually include risk factors which are gender- neutral and often lead to underestimate of CVD risk. There are factors in the life course of women that are unique and gender-specific which relate to long-term CVD risk. Pregnancy is considered a "cardiometabolic stress test" such that adverse pregnancy factors/outcomes in a woman, predict future CVD risk factors and incident CVD. The American Heart Association and American College of Cardiology Effectiveness-Based Guidelines for CVD Prevention in Women recommend taking a pregnancy history for CVD risk stratification, however it is unclear which pregnancy factors are independently related to CVD when taken together. Specific pregnancy factors that have been demonstrated to predict CVD risk factors and CVD include pregnancy- induced hypertension or pre-eclampsia, gestational diabetes, having a small for gestational age infant, a low or very high number of pregnancies, pre-term delivery, stillbirth and a history of subfertility. We believe thata pregnancy risk score derived from these candidate pregnancy factors will help medical caregivers determine which specific factors in a woman's pregnancy history are most important as far as predicting future CVD risk factors and future CVD. A pregnancy risk score may help providers with personalized, earlier referral for upstream risk factor modification and may also allow a woman to assess her own CVD risk. In this proposal, we have the following three research goals: 1. To determine which subset of pregnancy related factors is related to blood pressure, oral glucose tolerance test and lipid profile, in the V¿sterbotten Intervention Programme (VIP) when linked to the Swedish Population Registers (estimated n=16,041). 2. Utilize a multiple- marker approach to develop and validate a pregnancy factor risk index in the Swedish Population Registers (estimated n=800,000) and 3. To determine whether the pregnancy factor risk score (developed in specific AIM 2) improves CVD risk stratification (discrimination, calibration and net reclassification) above and beyond established CVD risk factors among women using the VIP dataset linked to Swedish Population Register.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2017 ( Subtotal = -$12,144 )
2017	2014	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 420	SAN FRANCISCO	CA	94103	SAN FRANCISCO	USA	Cardiovascular Diseases Research	000	2	8/18/2017	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	-$12,144
														Subtotal = -$12,144

Issue Date FY: 2016 ( Subtotal = $0 )
2016	2014	UNIVERSITY OF CALIFORNIA-SAN FRANCISCO	BOX 0812	SAN FRANCISCO	CA	94143	SAN FRANCISCO	USA	Cardiovascular Diseases Research	000	2	5/2/2016	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$0
														Subtotal = $0

Issue Date FY: 2014 ( Subtotal = $149,845 )
2014	2014	UNIVERSITY OF CALIFORNIA-SAN FRANCISCO	BOX 0812	SAN FRANCISCO	CA	94143	SAN FRANCISCO	USA	Cardiovascular Diseases Research	001	2	7/15/2014	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$149,845
2014	2013	QUEEN'S MEDICAL CENTER	1301 PUNCHBOWL STREET	HONOLULU	HI	96813	HONOLULU	USA	Cardiovascular Diseases Research	000	1	7/14/2014	NEW	$0
														Subtotal = $149,845

Issue Date FY: 2013 ( Subtotal = $296,411 )
2013	2013	QUEEN'S MEDICAL CENTER	1301 PUNCHBOWL STREET	HONOLULU	HI	96813	HONOLULU	USA	Cardiovascular Diseases Research	000	1	8/15/2013	NEW	$296,411
														Subtotal = $296,411

Grand Total All Awards = $434,112

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Pregnancy complications, future cardiovascular disease risk factors and cardiovas

Award Number: R21HL115398

ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 08/15/2013

PERIOD OF PERFORMANCE END DATE: 04/30/2017

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