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BIOMIMETIC DESIGN AND CONSTRUCTION OF AN ARTIFICIAL LUNG

Award Number: R21HL106585
ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 12/01/2010
PERIOD OF PERFORMANCE END DATE: 11/30/2013

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BIOMIMETIC DESIGN AND CONSTRUCTION OF AN ARTIFICIAL LUNG - The ultimate goal of this project is to develop artificial lung assist device technology to treat acute and chronic pulmonary failure. Chronic lung disease is the third-leading cause of death in the United States, exceeded only by heart disease and cancer. Currently there are no long-term solutions for chronic diseases such as Chronic Obstructive Pulmonary Disease (COPD) other than lung transplantation, and a severe shortage of donor organs limits this approach, leaving most patients relying on home oxygen therapy. For acute illnesses such as Adult Respiratory Distress Syndrome (ARDS), mechanical ventilation is typically required, and complications and mortality remain very high. Alternatives such as ExtraCorporeal Membrane Oxygenator (ECMO) therapy can only be used for a limited duration, require high levels of anticoagulation and involve numerous operational complexities. There is an urgent need for technological advances in artificial lung devices, including simplification and extended use of devices, a reduced need for anticoagulation, and high gas transfer rates in a compact format with low blood volumes. Here we propose an Exploratory Bioengineering Research Grant to pursue the development of technology for a bioartificial lung, based on biomimetic design principles and microfabrication technology to build scalable respiratory assist architectures capable of high levels of gas transport in a small and compact structure. Successful development of a bioartificial lung will require several critical elements, many of which have not been realized because of difficulties in mimicking natural lung physiology due to limitations in fabrication technology. The specific aims of this proposal are directed towards these elements, including the ability to design a biomimetic structure with small priming volume and high levels of gas permeability, and the establishment of an endothelialized microvascular network to support smooth blood flow without clotting in the absence of anticoagulative agents. These goals are consistent with future clinical targets including the ability to provide patients with long-term functional respiratory assist devices that do not require extensive anticoagulation and that can be enabled in a wearable or potentially implantable format. To accomplish these goals, we aim 1) To generate a biomimetic design and utilize microfabrication technology to construct an artificial lung module comprising microvascular networks and gas-permeable membranes, and 2) To establish endothelialized microfluidic network in vascular chamber and determine gas transport and blood flow coagulation properties of bioartificial lung construct.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2013 ( Subtotal = $0 )
2013	2012	Charles Stark Draper Laboratory, Inc.	555 Technology Sq	CAMBRIDGE	MA	02139	MIDDLESEX	USA	Cardiovascular Diseases Research	000	2	5/23/2013	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2012 ( Subtotal = $305,777 )
2012	2012	Charles Stark Draper Laboratory, Inc.	555 Technology Sq	CAMBRIDGE	MA	02139	MIDDLESEX	USA	Cardiovascular Diseases Research	000	2	11/16/2011	NON-COMPETING CONTINUATION	$275,199
2012	2012	Charles Stark Draper Laboratory, Inc.	555 Technology Sq	CAMBRIDGE	MA	02139	MIDDLESEX	USA	Cardiovascular Diseases Research	001	2	2/24/2012	NON-COMPETING CONTINUATION	$30,578
														Subtotal = $305,777

Issue Date FY: 2011 ( Subtotal = $260,714 )
2011	2011	Charles Stark Draper Laboratory, Inc.	555 Technology Sq	CAMBRIDGE	MA	02139	MIDDLESEX	USA	Cardiovascular Diseases Research	000	1	11/26/2010	NEW	$260,714
														Subtotal = $260,714

Grand Total All Awards = $566,491

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BIOMIMETIC DESIGN AND CONSTRUCTION OF AN ARTIFICIAL LUNG

Award Number: R21HL106585

ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 12/01/2010

PERIOD OF PERFORMANCE END DATE: 11/30/2013

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