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Developing a rapid and specific sensor for classic Galactosemia

Award Number: R21HD120747
ORGANIZATION: NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/07/2026
PERIOD OF PERFORMANCE END DATE: 08/31/2028

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Developing a rapid and specific sensor for classic Galactosemia - Current methods to diagnose Galactosemia relies on measuring residual enzymatic activity in dried blood spots using specialized equipment and technicians. Indeed, there are currently no devices that empower those suffering from Galactosemia and their caregivers by allowing them to self-monitor levels of galactose-1-phosphate – gal-1P, the cytotoxic intermediate largely responsible for the severity of classic Galactosemia. This works describes the development of gal-1P quantifying devices that may be used for clinical diagnosis as well as routine uses for in-home and clinical monitoring. This work leverages a gal-1P-specific phosphatase enzyme – newly discovered by the Nair lab – to ensure high accuracy, and the ease of use of electrochemical devices for metabolite quantification. The work synergizes the expertise of the Nair lab in enzyme engineering and characterization with that of the Mace lab in developing low-cost, paper-based devices for biomarker quantification.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $413,130 )
2026	2026	TRUSTEES OF TUFTS COLLEGE	80 GEORGE ST	MEDFORD	MA	02155	MIDDLESEX	USA	Child Health and Human Development Extramural Research	000	1	9/10/2026	NEW	$413,130
														Subtotal = $413,130

Grand Total All Awards = $413,130

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Developing a rapid and specific sensor for classic Galactosemia

Award Number: R21HD120747

ORGANIZATION: NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/07/2026

PERIOD OF PERFORMANCE END DATE: 08/31/2028

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