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Sucralose at the Maternal/Fetal Interface

Award Number: R21HD118469
ORGANIZATION: NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/10/2026
PERIOD OF PERFORMANCE END DATE: 09/09/2028

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Sucralose at the Maternal/Fetal Interface - PROJECT SUMMARY/ABSTRACT Non-nutritive Sweeteners (NNS) have been commonly used as food additives in the United States. They are now found ubiquitously in products like foods, beverages, medicines, lip balm, chewing gum, tabletop sweeteners, and yogurts. With an estimated 35% of adults consuming NNS daily, this is an intriguing societal trend pertinent for all ethnic groups, income levels, and social classes. While recommended for weight loss for decades, the World Health Organization (WHO) has recently re-evaluated its stance, prompting us to reassess their use and impact on us. Indeed, we have demonstrated that certain NNS, including sucralose, increased offspring toxicity during murine pregnancy and lactation. We have also demonstrated in vitro that sucralose inhibits the transporter P-Glycoprotein (PGP), increasing the cellular concentration of toxic compounds in liver cells. Because this transporter is also expressed in the placenta and is partly responsible for preventing the entry of toxic compounds in the fetal compartment, we wonder if sucralose also inhibits PGP at the maternal/fetal interface. We hypothesize that sucralose consumed during pregnancy might increase the entry of toxic compounds into and prevent the efflux of fetal waste products from the fetal compartment, creating a harmful environment for fetal development. We will verify this hypothesis by (1) assessing the inhibition by sucralose of similar transporters in the placenta and (2) measuring fetal retention of transporter substrates following maternal sucralose consumption.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $429,000 )
2026	2026	THE MEDICAL COLLEGE OF WISCONSIN, INC.	8701 WATERTOWN PLANK RD	MILWAUKEE	WI	53226	MILWAUKEE	USA	Child Health and Human Development Extramural Research	000	1	9/7/2026	NEW	$429,000
														Subtotal = $429,000

Grand Total All Awards = $429,000

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Sucralose at the Maternal/Fetal Interface

Award Number: R21HD118469

ORGANIZATION: NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/10/2026

PERIOD OF PERFORMANCE END DATE: 09/09/2028

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