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Childhood Adversity and Biological Mechanisms of Accelerated Aging

Award Number: R21HD115343
ORGANIZATION: NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/04/2024
PERIOD OF PERFORMANCE END DATE: 08/31/2026

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Childhood Adversity and Biological Mechanisms of Accelerated Aging - Project Summary/Abstract Early life adversity, including childhood maltreatment and other traumas, is a major risk factor for a host of health conditions, including psychiatric disorders, obesity, diabetes, and cardiovascular disease. Health behaviors, such as diet, sleep, and activity, are linked to childhood adversity and can further contribute to risk for these conditions. These effects compound over time and poor health outcomes are most evident in adults when biological effects of stress and health behaviors combine with age-related decline to produce frank disease. There is now evidence that these processes begin early in life and that some of the health outcomes can be observed in childhood. Converging evidence from animal models and recent human studies indicate that mitochondria play a key role in coordinating the stress response and in the aging process. Here we hypothesize that early stress alters mitochondrial DNA and mitochondrial function and that this may be a mechanism of risk for stress- and age-related disorders. The proposed study leverages data and specimens available in a longitudinal developmental study of childhood maltreatment that includes rich data on exposures, biomarkers of aging, and health outcomes. Results of this study are expected to provide insight into the biological mechanisms of adversity-related risk for accelerated aging and risk for disease, and provide targets for new treatment and prevention approaches.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $141,268 )
2025	2025	EMMA PENDLETON BRADLEY HOSPITAL	1011 VETERANS MEMORIAL PKWY	RIVERSIDE	RI	02915	PROVIDENCE	USA	Child Health and Human Development Extramural Research	001	2	8/18/2025	NON-COMPETING CONTINUATION	$141,268
2025	2024	EMMA PENDLETON BRADLEY HOSPITAL	1011 VETERANS MEMORIAL PKWY	RIVERSIDE	RI	02915	PROVIDENCE	USA	Child Health and Human Development Extramural Research	000	1	7/8/2025	NEW	$0
														Subtotal = $141,268

Issue Date FY: 2024 ( Subtotal = $274,595 )
2024	2024	EMMA PENDLETON BRADLEY HOSPITAL	1011 VETERANS MEMORIAL PKWY	RIVERSIDE	RI	02915	PROVIDENCE	USA	Child Health and Human Development Extramural Research	000	1	9/4/2024	NEW	$288,992
2024	2024	EMMA PENDLETON BRADLEY HOSPITAL	1011 VETERANS MEMORIAL PKWY	RIVERSIDE	RI	02915	PROVIDENCE	USA	Child Health and Human Development Extramural Research	001	1	9/10/2024	NEW	-$14,397
														Subtotal = $274,595

Grand Total All Awards = $415,863

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Childhood Adversity and Biological Mechanisms of Accelerated Aging

Award Number: R21HD115343

ORGANIZATION: NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/04/2024

PERIOD OF PERFORMANCE END DATE: 08/31/2026

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