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Role of congenital heart defects in motor skills and language acquisition of infants with Down syndrome

Award Number: R21HD115132
ORGANIZATION: NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 06/01/2024
PERIOD OF PERFORMANCE END DATE: 05/31/2027

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Role of congenital heart defects in motor skills and language acquisition of infants with Down syndrome - PROJECT SUMMARY Down syndrome (DS) is the most common genetic condition and causes significant development delays and weaknesses in the motor, cognitive, and language domains. About one half of infants with DS have congenital heart defects (CHD), resulting in slower development in infants with DS and CHD (i.e., DS+CHD) than those with DS without CHD (i.e., DS-CHD). Most of the earlier research used a cross-sectional design to compare the two groups by focusing on the attainment of milestones. Understanding of the process of motor and language skills (i.e., developmental trajectory) remains limited in infants with DS. The objectives of this proposal are to use mobile technology (smart devices and secure cloud storage) to collect motor (sitting and arm movement) and language (babbling) data in a home environment, employ computer vision software OpenPose to the motor data and behavioral coding to the language data, and examine motor-language interrelation in infants with DS+CHD and DS-CHD. Our central hypothesis is that sitting posture, rhythmic arm movement, and babbling are correlated in infants with DS, and infants with DS+CHD will show delayed acquisition and higher variability of sitting posture, rhythmic arm movement, and babbling, and a weaker motor-language interaction than those with DS-CHD. Aim 1: Validate mobile technology and computer vision in registering development trajectory of sitting posture and rhythmic arm movement in infants with DS+CHD and DS-CHD from 6 to 15 months of age. We will recruit 36 infants aged 6 months with DS+CHD and DS-CHD (n=18 in each). We will train the parents to collect 5-minute data of infant sitting and arm movement once a week using a provided iPad at their home. We will use OpenPose (computer vision software for pose estimation) to analyze trunk position and rhythmic arm movement. We will compare the trunk and arm data to that we collected from our monthly home visits to validate the application of mobile technology and computer vision in infants with DS. We hypothesize that trunk and arm data obtained with mobile technology and computer vision will serve as valid tools to register sitting posture and rhythmic arm movement and that DS+CHD will show a later acquisition of trunk control and arm movement than DS-CHD. Aim 2: Characterize interrelation between motor and language skills in infants with DS. We will record 10 minutes of parent-infant interaction at our monthly home visits to assess the emergence of babbling via behavioral coding. We will conduct multiple linear regression analysis with covariates of participants’ characteristics to examine an interaction between motor (trunk position and rhythmic arm movement) and language (babbling) in infants with DS. Further, we will utilize functional data analysis (e.g., function-on-function linear regression) to investigate interrelations (predictor and response) and causal effect of trunk position, rhythmic arm movement, and babbling. We hypothesize that trunk position and arm movement are correlated with babbling, and DS+CHD will display slower and more variable babbling acquisition and a weaker motor-language correlation than DS-CHD.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $0 )
2026	2025	GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION INC	58 EDGEWOOD AVE NE	ATLANTA	GA	30303	FULTON	USA	Child Health and Human Development Extramural Research	000	2	3/12/2026	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2025 ( Subtotal = $238,706 )
2025	2025	GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION INC	58 EDGEWOOD AVE NE	ATLANTA	GA	30303	FULTON	USA	Child Health and Human Development Extramural Research	000	2	5/20/2025	NON-COMPETING CONTINUATION	$238,706
														Subtotal = $238,706

Issue Date FY: 2024 ( Subtotal = $203,140 )
2024	2024	GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION INC	58 EDGEWOOD AVE NE	ATLANTA	GA	30303	FULTON	USA	Child Health and Human Development Extramural Research	000	1	5/27/2024	NEW	$203,140
														Subtotal = $203,140

Grand Total All Awards = $441,846

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Role of congenital heart defects in motor skills and language acquisition of infants with Down syndrome

Award Number: R21HD115132

ORGANIZATION: NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 06/01/2024

PERIOD OF PERFORMANCE END DATE: 05/31/2027

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