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Game-based Mobile-Health Quantification of Upper-Limb Motor Performance in Children with Hemiparetic Cerebral Palsy

Award Number: R21HD114094
ORGANIZATION: NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 08/01/2024
PERIOD OF PERFORMANCE END DATE: 07/31/2026

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Game-based Mobile-Health Quantification of Upper-Limb Motor Performance in Children with Hemiparetic Cerebral Palsy - PROJECT SUMMARY The main goal of this research project is to test and validate a mobile health (mHealth) application to quantify upper limb motor performance in children with hemiparetic cerebral palsy (HCP). Movement impairments impact activities of daily living and performance of functional activities, thus limiting children’s participation and quality of life. Rigorous and quantifiable assessments provide key data for treatment planning and offer insight into the pathophysiology of motor impairments. Clinical assessments of the upper-limb can be subjective, require in-person visits with trained personnel, and specialized equipment. Alternatively, laboratory assessments are quantifiable and precise but also require in-person visits with specialized equipment. Existing mobile technology, such as the iPad tablet, offers the potential for objective and quantifiable measurement in any environment. As a first step in this research, we will test the reliability, validity, and usability of a mobile health (mHealth) application to measure upper limb movement performance in a controlled-laboratory setting. Our team has developed an mHealth application for the iPad featuring interactive games to quantify upper-limb movement performance. Children with HCP and typically-developing age-matched children will participate in the study consisting of two in-person visits to a laboratory. During each session, they will play five mHealth movement games requiring visually-guided multi-joint movements, fine motor and finger control, and bimanual coordination. In Aim 1, we will determine the reliability, validity, and usability of the mHealth application. Test- retest reliability and concurrent validity with 3D optical motion capture will be evaluated; usability will be evaluated with a standardized mHealth questionnaire. In Aim 2, we will further examine the validity of the mHealth application by comparing motor performance outcomes with other standardized assessments and questionnaires of the upper-limb that span multiple ICF domains (body function, activity, and participation). If successful, mobile technology may be implemented in a follow-up cohort study to study longitudinal upper-limb motor development, recovery, and response to neurorehabilitation interventions in children with HCP. More broadly, the outcomes of this research will impact how and where motor evaluations can be performed, offering a flexible methodology for researchers performing longitudinal and telerehabilitation studies. Importantly, mobile technology offers an option for remote participation that may significantly expand the participant pool, allowing for more diverse and representative samples in future work.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $236,876 )
2025	2025	MARQUETTE UNIVERSITY	313 N 13TH ST	MILWAUKEE	WI	53233	MILWAUKEE	USA	Child Health and Human Development Extramural Research	000	2	7/18/2025	NON-COMPETING CONTINUATION	$236,876
														Subtotal = $236,876

Issue Date FY: 2024 ( Subtotal = $206,128 )
2024	2024	MARQUETTE UNIVERSITY	313 N 13TH ST	MILWAUKEE	WI	53233	MILWAUKEE	USA	Child Health and Human Development Extramural Research	000	1	7/31/2024	NEW	$206,128
														Subtotal = $206,128

Grand Total All Awards = $443,004

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Game-based Mobile-Health Quantification of Upper-Limb Motor Performance in Children with Hemiparetic Cerebral Palsy

Award Number: R21HD114094

ORGANIZATION: NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 08/01/2024

PERIOD OF PERFORMANCE END DATE: 07/31/2026

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