Thursday, April 25, 2024 4/25/2024

Burden and Risk of Neurological and Cognitive Impairment in Pediatric Sickle Cell Anemia in Uganda

Award Number: R21HD089791
ORGANIZATION: NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

Group Awards By Issue Date FY or Funding FY:

View Award Abstract

Burden and Risk of Neurological and Cognitive Impairment in Pediatric Sickle Cell Anemia in Uganda Sickle Cell Anemia (SCA) is the most common inherited disorder in sub-Saharan Africa. In Uganda, an estimated 20,000 children are born with SCA annually. Vasculopathy in SCA is associated with brain injury and affect neurologic and cognitive function. Brain injury in pediatric SCA may follow acute inflammatory events, including infections. Acute bacterial, malarial and other infections and malnutrition are highly prevalent in SSA, and may contribute to or precipitate SCA vascular brain injury. Our goal is to establish the burden and clinical spectrum of pediatric brain injury from SCA, identify risk factors, and build research capacity to support interventions for brain injury reduction. Our hypothesis is that risk factors (sickle vasculopathy, malnutrition, other) independently or with triggers (inflammation or infections) predispose children with SCA in SSA to a high burden of neurological and cognitive impairments. The objectives of this application are to determine the age-related spectrum and burden of brain injury associated with SCA in Ugandan children, and determine the predisposing risk factors. Knowledge of the magnitude of brain injury from SCA and the underlying risk factors will drive the design of future studies on pathogenesis and preventive measures to improve outcome. In response to PAR-14-331, we propose to: Aim 1. Determine the burden and spectrum of neurological and cognitive impairment in children with SCA aged 0-12 years in Uganda; Aim 2. Examine risk factors or triggers for neurological and cognitive impairment in children with SCA in the same sample; and Aims 3. Enhance existing brain research capacity in Uganda through the study of pediatric neurologic and cognitive impairment in SCA. Through this work, we will have established an estimate of the burden, spectrum and associated risk factors and triggers for brain injury in children with SCA in Uganda, a SCA repository; developed a cohort to follow prospectively; inform the design of prospective studies to understand the pathogenesis and test interventions to reduce the burden of brain injury in SCA in Uganda; and increased capacity for carrying out north-south and south-south research collaborations in SCA and will fill a substantial gap in our institutional, national and regional capacity in brain research and training across the lifespan.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2022 ( Subtotal = $27 )
2022	2018	MAKERERE UNIVERSITY COLLEGE O F HEALTH SCIENCES	CLINICAL RESEARCH BUILDING NEW MULAGO HILL ROAD	KAMPALA				UGA	Child Health and Human Development Extramural Research	000	2	9/26/2022	SUPPLEMENT FOR EXPANSION	$27
														Subtotal = $27

Issue Date FY: 2020 ( Subtotal = -$36 )
2020	2018	MAKERERE UNIVERSITY COLLEGE O F HEALTH SCIENCES	NEW MULAGO HOSPITAL COMPLEX	KAMPALA				UGA	Child Health and Human Development Extramural Research	000	2	11/20/2019	SUPPLEMENT FOR EXPANSION	-$36
														Subtotal = -$36

Issue Date FY: 2018 ( Subtotal = $49,992 )
2018	2018	MAKERERE UNIVERSITY COLLEGE O F HEALTH SCIENCES	NEW MULAGO HOSPITAL COMPLEX	KAMPALA				UGA	Child Health and Human Development Extramural Research	000	2	8/23/2018	SUPPLEMENT FOR EXPANSION	$49,992
														Subtotal = $49,992

Issue Date FY: 2017 ( Subtotal = $135,000 )
2017	2017	MAKERERE UNIVERSITY COLLEGE O F HEALTH SCIENCES	NEW MULAGO HOSPITAL COMPLEX	KAMPALA				UGA	Child Health and Human Development Extramural Research	000	2	8/8/2017	NON-COMPETING CONTINUATION	$135,000
														Subtotal = $135,000

Issue Date FY: 2016 ( Subtotal = $132,880 )
2016	2016	MAKERERE UNIVERSITY COLLEGE OF HEALTH SCIENCES	1ST FL CLINICAL RESEARCH BLDG	KAMPALA				UGA	Child Health and Human Development Extramural Research	001	1	8/22/2016	NEW	$0
2016	2016	MAKERERE UNIVERSITY COLLEGE OF HEALTH SCIENCES	1ST FL CLINICAL RESEARCH BLDG	KAMPALA				UGA	Child Health and Human Development Extramural Research	000	1	8/17/2016	NEW	$132,880
														Subtotal = $132,880

Grand Total All Awards = $317,863

Top

All Categories

About

Search

Reports

Data Submission

Award Information

Burden and Risk of Neurological and Cognitive Impairment in Pediatric Sickle Cell Anemia in Uganda

Award Number: R21HD089791

ORGANIZATION: NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

Federal Websites

Department of Health & Human Services

HHS Operating Divisions

HHS Staff Divisions

Download A Document Viewer