Official websites use .gov

A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS

A lock ( 🔒 ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

Need Help

Method development for simultaneous automatic assignment and structure determination in protein NMR

Award Number: R21GM143507
ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/12/2022
PERIOD OF PERFORMANCE END DATE: 08/31/2025

Group Awards By:

View Award Description

Method development for simultaneous automatic assignment and structure determination in protein NMR - Protein NMR is a powerful tool for studying protein structure, dynamics and interactions at atomic resolution. However, currently it is time-consuming and laborious to obtain NMR resonance assignment and the NMR structure of a protein. Here we will leverage recent advances in Euclidean distance geometry to develop a method for simultaneous determination of resonance assignment and protein structure using only the NOESY spectra. We have two aims: 1. Method development and validation using synthetic data based on known protein structure; 2 Method development and validation using experimental NMR data.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = -$1,810 )
2026	2023	RENSSELAER POLYTECHNIC INSTITUTE	110 8TH ST	TROY	NY	12180	RENSSELAER	USA	Biomedical Research and Research Training	000	2	4/29/2026	NON-COMPETING CONTINUATION	-$1,810
														Subtotal = -$1,810

Issue Date FY: 2023 ( Subtotal = $192,814 )
2023	2023	RENSSELAER POLYTECHNIC INSTITUTE	110 8TH ST	TROY	NY	12180	RENSSELAER	USA	Biomedical Research and Research Training	000	2	8/17/2023	NON-COMPETING CONTINUATION	$192,814
														Subtotal = $192,814

Issue Date FY: 2022 ( Subtotal = $223,395 )
2022	2022	RENSSELAER POLYTECHNIC INSTITUTE	110 8TH ST	TROY	NY	12180	RENSSELAER	USA	Biomedical Research and Research Training	000	1	9/8/2022	NEW	$223,395
														Subtotal = $223,395

Grand Total All Awards = $414,399

Top

All Categories

About

Search

Reports

Data Submission

Award Information

Method development for simultaneous automatic assignment and structure determination in protein NMR

Award Number: R21GM143507

ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/12/2022

PERIOD OF PERFORMANCE END DATE: 08/31/2025

Federal Websites

Department of Health & Human Services

HHS Operating Divisions

HHS Staff Divisions

Download A Document Viewer