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A role for retinal waves in vascular development

Award Number: R21EY037926
ORGANIZATION: NATIONAL EYE INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/01/2025
PERIOD OF PERFORMANCE END DATE: 08/31/2026

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A role for retinal waves in vascular development - Understanding the signaling between neurons, glial cells, and blood vessels during development is crucial for designing treatments for vasculature defects, such as the over-vascularization associated with retinopathy of prematurity. The proposal aims to determine the role of neural-glial-vascular signaling in vasculature development through two main objectives: Aim 1: Use quantitative approaches to characterize the vasculature development and to assess how this process is altered in mice with altered retinal waves. We also propose to use live imaging of vasculature growth to assess the nature of dividing vessel maturation. Aim 2: Establish the maturation of the glial-vascular unit using two approaches. First, we will use immunofluorescence to assess when the glial-vascular interface arises during development. Second, we will use two-photon calcium imaging to monitor the spontaneous calcium transients in glial processes associated with vasculature and establish their correlation with retinal waves. This research will enable the lab to test novel hypotheses regarding the role of signaling in vasculature development, which is critical for understanding how neural activity influences normal and pathological vasculature development.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $240,750 )
2025	2025	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	1608 4TH ST STE 201	BERKELEY	CA	94710	ALAMEDA	USA	Vision Research	000	1	8/15/2025	NEW	$240,750
														Subtotal = $240,750

Grand Total All Awards = $240,750

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A role for retinal waves in vascular development

Award Number: R21EY037926

ORGANIZATION: NATIONAL EYE INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/01/2025

PERIOD OF PERFORMANCE END DATE: 08/31/2026

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