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Inhibiting Corneal Neovascularization by Targeting Tissue Factor

Award Number: R21EY037451
ORGANIZATION: NATIONAL EYE INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 08/01/2025
PERIOD OF PERFORMANCE END DATE: 07/31/2027

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Inhibiting Corneal Neovascularization by Targeting Tissue Factor - Project Summary Cornea is a transparent tissue without any vasculature. Diseases and injuries that compromise the optical clarity of the cornea are the third most common cause of blindness worldwide. A common sequela of these corneal diseases and injuries is the growth of pathological vessels, a process known as corneal neovascularization (CNV). To date, there is no specific therapy for CNV, underscoring the need to identify effective treatments for this disease. Tissue factor (TF) is a well-known factor for blood coagulation after blood vessel injury. Under physiological condition, TF is strictly expressed in cells underneath the endothelial cells, such as pericytes. Preliminary study revealed that TF level was low in uninjured mouse corneas and was upregulated after alkali injury. In the proposed work, TF as a potential biomarker for CNV and an immuno-conjugate that targets TF as a potential therapy to treat CNV will be investigated.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $433,125 )
2025	2025	OHIO STATE UNIVERSITY, THE	1960 KENNY RD	COLUMBUS	OH	43210	FRANKLIN	USA	Vision Research	000	1	7/11/2025	NEW	$433,125
														Subtotal = $433,125

Grand Total All Awards = $433,125

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Inhibiting Corneal Neovascularization by Targeting Tissue Factor

Award Number: R21EY037451

ORGANIZATION: NATIONAL EYE INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 08/01/2025

PERIOD OF PERFORMANCE END DATE: 07/31/2027

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