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Quantitative characterization of vitreous degeneration in myopia

Award Number: R21EY024434
ORGANIZATION: NATIONAL EYE INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 01/01/2015
PERIOD OF PERFORMANCE END DATE: 12/31/2016

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Quantitative characterization of vitreous degeneration in myopia - DESCRIPTION (provided by applicant): The ultimate goal of this project is to develop a quantitative, ultrasound-based assessment of the vitreous as it relates to vitreo-retinal diseases, such as myopia and diabetic retinopathy, at an early stage before severe outcomes (e.g., blindness) occur. Normal age-related changes (e.g., collagen cross-linking and aggregation, liquefaction, cellular debris, etc.) create inhomogeneities, such as floaters, to appear throughout the vitreous in a non-uniform distribution; these inhomogeneities can serve as weak acoustic scatterers. Concurrent changes at the vitreo-retinal interface weaken the adhesion of the posterior vitreous cortex to the internal limiting lamina of the retina, resulting in posterior viteous detachment. For patients with myopia, these normal processes do not typically occur in tandem because liquefaction is accelerated and the vitreous destabilizes before the vitreous adhesion to the retina is weakened. No diagnostic method is now available to characterize the changes taking place throughout the vitreous volume at an early stage before irreversible pathologies have developed or to determine how these changes relate to progression of diseases. Thus, a clinical need exists to detect within the vitreous the macromolecular changes and structural precursors related to vitreo-retinal disease. We will assemble a novel, high-resolution, annular-array ultrasound system capable of acquiring image data of the entire vitreous and then use quantitative ultrasound methods to characterize vitreous inhomogeneities based on parameters derived from raw ultrasound backscatter signals. The system will utilize state-of-the-art, 20-MHz, annular-array technology to achieve an unprecedented improvement in depth-of-field, resolution and sensitivity relative to current clinical ultrasound technology. The proposed technology will overcome limitations of optical coherence tomography, such as its restricted lateral view through the pupil (due to opaque intervening structures such as the iris, sclera, and possibly cataracts) and its inability to image optically transparent tissue. The early stages of th project will emphasize assembling a hand-held clinical prototype annular-array system and developing signal-processing methods. Later stages will focus on human-subject imaging and quantification of vitreous inhomogeneities occurring during normal aging and myopia.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2017 ( Subtotal = -$15,717 )
2017	2016	RIVERSIDE RESEARCH INSTITUTE	156 WILLIAM ST 9TH FL	NEW YORK	NY	10038	NEW YORK	USA	Vision Research	000	2	6/2/2017	NON-COMPETING CONTINUATION	-$15,717
														Subtotal = -$15,717

Issue Date FY: 2016 ( Subtotal = $198,419 )
2016	2016	RIVERSIDE RESEARCH INSTITUTE	156 WILLIAM STREET, NINTH FL	MANHATTAN	NY	10038	NEW YORK	USA	Vision Research	001	2	1/29/2016	NON-COMPETING CONTINUATION	$19,842
2016	2016	RIVERSIDE RESEARCH INSTITUTE	156 WILLIAM STREET, NINTH FL	MANHATTAN	NY	10038	NEW YORK	USA	Vision Research	000	2	1/11/2016	NON-COMPETING CONTINUATION	$178,577
														Subtotal = $198,419

Issue Date FY: 2015 ( Subtotal = $234,141 )
2015	2015	RIVERSIDE RESEARCH INSTITUTE	156 WILLIAM STREET, NINTH FL	MANHATTAN	NY	10038	NEW YORK	USA	Vision Research	000	1	12/10/2014	NEW	$234,141
														Subtotal = $234,141

Grand Total All Awards = $416,843

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Quantitative characterization of vitreous degeneration in myopia

Award Number: R21EY024434

ORGANIZATION: NATIONAL EYE INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 01/01/2015

PERIOD OF PERFORMANCE END DATE: 12/31/2016

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