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Wearable ultrasound patch for noninvasive hemodynamic monitoring after pediatric cardiac surgery

Award Number: R21EB040377
ORGANIZATION: NATIONAL INSTITUTE Of BIOMEDICAL IMAGING & BIOENGINEERING
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 08/15/2026
PERIOD OF PERFORMANCE END DATE: 07/31/2028

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Wearable ultrasound patch for noninvasive hemodynamic monitoring after pediatric cardiac surgery - Significance. Neonates and infants undergoing cardiac surgery face a high risk of postoperative hemodynamic instability, leading to low cardiac output syndrome (LCOS), graft failure, and severe hemodynamic compromise, with mortality rates reaching 50% in transplant cases and 34% for delayed sternal closure (DSC). Despite 40,000 pediatric cardiac surgeries performed annually in the U.S., no real-time, continuous hemodynamic monitoring monitoring solution exists. Current methods are intermittent, indirect, or invasive, making long-term bedside monitoring impractical and delaying early intervention for hemodynamic complications. Objectives. This project aims to develop a disposable wearable ultrasound patch for real-time, noninvasive monitoring of cardiac output and blood pressure in neonates and infants (0–1 year). The ultrasound patch and associated instrumentation and signal processing algorithms will be validated through benchtop experiments and in vivo feasibility will be demonstrated through experiments in an juvenile pig model. Innovation. The proposed project introduces three innovations: (1) a miniaturized disposable ultrasound patch fabricated using additive manufacturing techniques; (2) a novel tunable steering array; and (3) novel signal processing and instrumentation for angle-independent blood velocity and arterial pulse wave velocity assessment. Approach. The disposable ultrasound patch will be fabricated using an innovative one-step laser patterning and 3D printing process. A tunable array will be controlled using stepped frequency modulated continuous wave signals, and the received data will be analyzed using vector Doppler signal processing algorithms. The transducer, instrumentation and signal processing algorithms will be validated against conventional methods for flow and pressure measurements through benchtop acoustic characterization and flow phantom fluid dynamics experiements, and through an in vivo study in an animal model. Impact. By providing a noninvasive continuous hemodynamic monitoring solution, this project has the potential to transform pediatric cardiovascular care by enabling early complication detection, reducing invasive procedures, and improving surgical outcomes. The probe’s innovations extend to vascular and transplant surgeries, where continuous graft perfusion monitoring is critical. Additionally, the pediatric phantom model will serve as a standardized platform for testing next-generation ultrasound-based diagnostic tools. By advancing real-time, noninvasive hemodynamic monitoring, this project supports the NIH’s mission to drive biomedical innovation and improve healthcare outcomes, accelerating the clinical translation of bioelectronic solutions for both pediatric and adult cardiovascular care.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $265,018 )
2026	2026	GEORGE MASON UNIVERSITY	4400 UNIVERSITY DR	FAIRFAX	VA	22030	FAIRFAX CITY	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	1	8/14/2026	NEW	$265,018
														Subtotal = $265,018

Grand Total All Awards = $265,018

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Wearable ultrasound patch for noninvasive hemodynamic monitoring after pediatric cardiac surgery

Award Number: R21EB040377

ORGANIZATION: NATIONAL INSTITUTE Of BIOMEDICAL IMAGING & BIOENGINEERING

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 08/15/2026

PERIOD OF PERFORMANCE END DATE: 07/31/2028

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