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Multi-Modal, Multi-Depth, High Resolution Micro-Endoscope (M3D-HRME) for early cancer diagnostics

Award Number: R21EB038806
ORGANIZATION: NATIONAL INSTITUTE Of BIOMEDICAL IMAGING & BIOENGINEERING
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 08/03/2026
PERIOD OF PERFORMANCE END DATE: 07/31/2028

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Multi-Modal, Multi-Depth, High Resolution Micro-Endoscope (M3D-HRME) for early cancer diagnostics - Multi-Modal, Multi-Depth, High Resolution Micro-Endoscope (M3D-HRME) for early cancer diagnostics Work pursued within this proposal will carry out feasibility studies to develop a new class of optical micro-endoscopic devices for early stage, cancer detection. The proposed solution will combine advances in state-of the art fabrication technologies to manufacture integrated miniature multi-lens objectives that will be combined with High Resolution Micro-Endoscope (HRME) for an efficient Multi-Modal, Multi-Depth cancer diagnostic imaging (called M3D- HRME). A set of mini-objectives will be integrated along the waveguide structures (fabricated in same process) imaging system, and enabled by 2-Photon Polymerization based additive manufacturing. The multi-lens unit will be printed directly on the top of the polished imaging fiber bundles. Its outer form will conform to the fiber bundle dimensions. The mini objectives included in the unit will provide different resolutions and/or imaging depths. The probe will be capable of front imaging as well as side viewing –internal wall of luminal structures like the cervical os for example. M3D-HRME will be used by moving it in contact across the tissue and real time mosaicked to provide complementary imaging sets – morphology (outer tissue layer) and microvasculature (70-140 microns below the top tissue layer). Note that there is clinical evidence that angiogenesis patterns change with dysplasia along with the changes in nuclear morphology. To accomplish project goals we will develop prototypes of multi-unit refractive rod-like objectives. M3D-HRME will provide 2-micron resolution (fluorescence - morphology) working along objective pairs to image 70-140 microns depths with 15-20 microns resolution (in dark field mode - microvasculature). The refractive changes to produce the multi-lens objectives will be obtained by modulating the laser power during 2-photon polymerization. In addition we will test system imaging metrics using in target and tissue imaging experiments. For example, we will evaluate imaging performance in normal volunteers imaging epithelial layer in oral cavity as well as in-vitro cervical tissue samples. Both front and side view imaging will be performed to assess system in both modes for future cervical cancer applications.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $182,736 )
2026	2026	WILLIAM MARSH RICE UNIVERSITY	6100 MAIN ST	HOUSTON	TX	77005	HARRIS	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	1	8/3/2026	NEW	$182,736
														Subtotal = $182,736

Grand Total All Awards = $182,736

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Multi-Modal, Multi-Depth, High Resolution Micro-Endoscope (M3D-HRME) for early cancer diagnostics

Award Number: R21EB038806

ORGANIZATION: NATIONAL INSTITUTE Of BIOMEDICAL IMAGING & BIOENGINEERING

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 08/03/2026

PERIOD OF PERFORMANCE END DATE: 07/31/2028

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