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A Novel Drug Delivery Platform for Targeted Ovarian Cancer Treatment

Award Number: R21EB038549
ORGANIZATION: NATIONAL INSTITUTE Of BIOMEDICAL IMAGING & BIOENGINEERING
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/04/2026
PERIOD OF PERFORMANCE END DATE: 08/31/2029

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A Novel Drug Delivery Platform for Targeted Ovarian Cancer Treatment - Project Summary Ovarian cancer is the deadliest gynecologic tumor, responsible for hundreds of thousands of deaths each year, according to the American Cancer Society (ACS). While chemotherapy remains the essential component of the ovarian cancer treatment protocol, its efficacy is significantly compromised by the systematic side effects of chemotherapeutic agents and the high risk of recurrence due to the development of chemoresistance. Therefore, there is an urgent, unmet need to develop an innovative controlled drug delivery platform that can simultaneously minimize the systematic toxicity of anti-tumor drugs and improve the chemotherapeutic efficacy of ovarian cancer treatment. Electrospinning technique is a modern, versatile, and advanced technique that uses electrified polymeric jets traveling across an electrical field to form micro/nanofibers. This technique has gained much interest in drug delivery research owing to its simplicity, versatility, relatively low cost, and the fact that it can be carried out at room temperature, thus preventing the degradation of proteins and polymers. In this grant proposal, we propose to develop a novel, modular multi-drug delivery platform using the electrospinning technique for ovarian cancer treatment applications through an implantation-based clinical administration route. The proposed platform is designed to be implantable near ovarian tumors, allowing for site- specific drug delivery that reduces systemic toxicity compared to traditional chemotherapy. The proposed research will focus on developing and optimizing the electrospun drug delivery fibers, followed by in vitro and in vivo evaluations of their stability, drug release, and therapeutic efficacy using high-grade serous ovarian cancer (HGSOC) cells and animal models. The long-term goal of this pilot project is to develop a novel, customizable drug-delivery platform that can minimize systematic drug toxicity, improve chemotherapeutic and immunotherapeutic efficacy, and be tailored to individual patient needs, thus enhancing the treatment outcome and reducing ovarian cancer recurrence. Furthermore, this platform can be adapted and extended for the localized treatment of other solid tumors, increasing its potential impact in cancer therapy.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $232,500 )
2026	2026	UNIVERSITY OF MISSISSIPPI MEDICAL CENTER	2500 N STATE ST	JACKSON	MS	39216	HINDS	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	1	9/4/2026	NEW	$232,500
														Subtotal = $232,500

Grand Total All Awards = $232,500

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A Novel Drug Delivery Platform for Targeted Ovarian Cancer Treatment

Award Number: R21EB038549

ORGANIZATION: NATIONAL INSTITUTE Of BIOMEDICAL IMAGING & BIOENGINEERING

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/04/2026

PERIOD OF PERFORMANCE END DATE: 08/31/2029

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