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Catch and Release Radiolabeled Peptides: a new technology for radiotracer development

Award Number: R21EB032495
ORGANIZATION: NATIONAL INSTITUTE Of BIOMEDICAL IMAGING & BIOENGINEERING
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 07/15/2023
PERIOD OF PERFORMANCE END DATE: 06/30/2027

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Catch and Release Radiolabeled Peptides: a new technology for radiotracer development - PROJECT SUMMARY Radiolabeled peptides are emerging as a very valuable class of radiotracers that are seated in a unique chemical space, exploiting many of the advantages of small molecules and large biomolecules. To date, they have mostly been used in the oncology field for imaging and treatment. Important to note that peptides are widely sought in drug development for the same reasons. This mass appeal is mostly in part to the high density of chirality and functionality that peptides possess as well as their ease of synthesis which has significantly benefited from automation. In addition, several technologies exist, like one-bead-one-compound libraries and phage display approaches that render discovering biologically-relevant, target-specific peptides quite easy. A new twist on some very old chemistry has paved the way for a new technology in the radiolabeling of peptides that yields high purity, high molar activity tracers in biologically compatible formulation without need for costly reconstitution and purification steps, and can potentially be fully integrated into existing automated peptide synthesis. A technology like this would tremendously benefit the synthesis, evaluation and clinical translation of peptide radiotracers. Beyond this, however, this technology offers new opportunities to integrate positron emission labeled molecules in drug discovery and pharmacology. A robust and automated platform to radiolabel a richly diverse class of molecules could be used to assess collections of molecules in single molecular interactions, in cells and in living biological systems. The goal of this proposal is the development of a new radiolabeling technical platform for peptides and apply it to a group of phage-selected antimicrobial peptides. The study of this group of labeled compounds will be conducted in parallel to assist in the discovery of new biologically-relevant, target-specific peptides, as well as, gaining fundamental understanding of the structure and function relationships of groups of peptides. The information gathered from this project will play in important role in the development of new imaging agents and therapies.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $201,888 )
2026	2026	THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK	W5510 FRANKS MELVILLE MEMORIAL LIBRARY	STONY BROOK	NY	11794	SUFFOLK	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	4	6/15/2026	NON-COMPETING CONTINUATION	$201,888
														Subtotal = $201,888

Issue Date FY: 2025 ( Subtotal = $1 )
2025	2025	THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK	W5510 FRANKS MELVILLE MEMORIAL LIBRARY	STONY BROOK	NY	11794	SUFFOLK	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	001	3	6/30/2025	NON-COMPETING CONTINUATION	$1
2025	2025	THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK	W5510 FRANKS MELVILLE MEMORIAL LIBRARY	STONY BROOK	NY	11794	SUFFOLK	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	002	3	7/24/2025	NON-COMPETING CONTINUATION	$0
2025	2024	THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK	W5510 FRANKS MELVILLE MEMORIAL LIBRARY	STONY BROOK	NY	11794	SUFFOLK	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	2	10/10/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $1

Issue Date FY: 2024 ( Subtotal = $201,889 )
2024	2024	THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK	W5510 FRANKS MELVILLE MEMORIAL LIBRARY	STONY BROOK	NY	11794	SUFFOLK	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	2	6/28/2024	NON-COMPETING CONTINUATION	$201,889
														Subtotal = $201,889

Issue Date FY: 2023 ( Subtotal = $241,764 )
2023	2023	THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK	W5510 FRANKS MELVILLE MEMORIAL LIBRARY	STONY BROOK	NY	11794	SUFFOLK	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	1	7/11/2023	NEW	$241,764
														Subtotal = $241,764

Grand Total All Awards = $645,542

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Catch and Release Radiolabeled Peptides: a new technology for radiotracer development

Award Number: R21EB032495

ORGANIZATION: NATIONAL INSTITUTE Of BIOMEDICAL IMAGING & BIOENGINEERING

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 07/15/2023

PERIOD OF PERFORMANCE END DATE: 06/30/2027

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