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Film-like Acoustic Microresonators for Wireless Monitoring of Intracardiac Pressure using Ultrasound

Award Number: R21EB030654
ORGANIZATION: NATIONAL INSTITUTE Of BIOMEDICAL IMAGING & BIOENGINEERING
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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Film-like Acoustic Microresonators for Wireless Monitoring of Intracardiac Pressure using Ultrasound - Abstract While wireless monitoring of intracardiac pressure using implants is essential for the management of heart failure, miniaturizing these implants is critical for reducing their associated complications. Current implants mainly consist of an electromagnetic antenna, electronics, and energy-storage and conversion units. However, these units contain toxic materials, and a large antenna is necessary to transmit the large wavelengths (>5 cm) of electromagnetic waves. The size and inorganic components of the current implants increase the risk of complications for patients. Ultrasound technology is promising to replace electromagnetic waves for in vivo wireless communications. It is safe, does not interfere with other electromagnetic signals, has lower in vivo signal attenuation, and permits the use of significantly smaller antennas and implants due to its sub-millimeter wavelength. Therefore, communication through ultrasound is ideal for use in minimally invasive pressure monitoring implants. The long- term objective is to develop an ultrasound-based, wireless technology that will miniaturize intracardiac implants by eliminating both the electromagnetic antenna and the energy storage and conversion units. The objective of this project is to utilize flexible, acoustic microresonators (100 to 500 µm thick films) with compressible microcavities for physiological pressure measurements of atriums and ventricles. Our central hypothesis is that the post-processing of echo signals from the resonators and their resonant frequencies can detect intracardiac pressure changes. Our rationale is that micro-fabricated films made from polydimethylsiloxane (PDMS) form acoustic resonators. Incorporating gas/void filled microcavities into the PDMS film creates a resonator that is sensitive to the pressure difference between the inside and outside. Changing the differential pressure causes deformations of the resonator. These deformations shift the film's resonant frequency allowing for the detection of pressure changes. Our specific aims are to 1) prove the measurement sensitivity of the resonator underwater at the ventricular and atrial physiological pressures with the resolution of ~1mmHg and temporal resolution of 40 (ms); 2) demonstrate the safety of an implantable device in vitro by incorporating hemocompatible materials, testing a device's durability, and testing in a specially designed phantom; and 3) prove that the implant is suitable for a minimally invasive delivery (transseptal procedure) on a benchtop test setup. Upon project completion, the technology can be immediately employed to create safer next-generation in vivo pressure monitoring implants that operate solely using acoustic waves. This contribution is significant because it can aid over 6 million Americans who live with Heart Failure (HF), resulting in chronic hospitalizations that cost $16 billion. The proposed research is innovative because this technology employs only acoustic waves; avoids energy conversion, storage units, and electromagnetic antennas; and significantly reduces an implant's size and complications.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $0 )
2025	2024	NEW MEXICO STATE UNIVERSITY	1050 STEWART ST.	LAS CRUCES	NM	88003	DONA ANA	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	3	1/27/2025	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2024 ( Subtotal = $133,915 )
2024	2024	NEW MEXICO STATE UNIVERSITY	1050 STEWART ST.	LAS CRUCES	NM	88003	DONA ANA	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	3	2/14/2024	NON-COMPETING CONTINUATION	$120,524
2024	2024	NEW MEXICO STATE UNIVERSITY	1050 STEWART ST.	LAS CRUCES	NM	88003	DONA ANA	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	001	3	6/7/2024	NON-COMPETING CONTINUATION	$13,391
														Subtotal = $133,915

Issue Date FY: 2023 ( Subtotal = $0 )
2023	2022	NEW MEXICO STATE UNIVERSITY	1050 STEWART ST STE E1200	LAS CRUCES	NM	88003	DONA ANA	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	2	3/1/2023	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2022 ( Subtotal = $189,748 )
2022	2022	NEW MEXICO STATE UNIVERSITY	1050 STEWART ST STE E1200	LAS CRUCES	NM	88003	DONA ANA	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	001	2	8/3/2022	NON-COMPETING CONTINUATION	$18,976
2022	2022	NEW MEXICO STATE UNIVERSITY	1050 STEWART ST STE E1200	LAS CRUCES	NM	88003	DONA ANA	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	2	1/31/2022	NON-COMPETING CONTINUATION	$170,772
														Subtotal = $189,748

Issue Date FY: 2021 ( Subtotal = $256,981 )
2021	2021	NEW MEXICO STATE UNIVERSITY	1050 STEWART ST STE E1200	LAS CRUCES	NM	88003	DONA ANA	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	001	1	5/28/2021	NEW	$0
2021	2021	NEW MEXICO STATE UNIVERSITY	1050 STEWART ST STE E1200	LAS CRUCES	NM	88003	DONA ANA	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	1	4/22/2021	NEW	$256,981
														Subtotal = $256,981

Grand Total All Awards = $580,644

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Film-like Acoustic Microresonators for Wireless Monitoring of Intracardiac Pressure using Ultrasound

Award Number: R21EB030654

ORGANIZATION: NATIONAL INSTITUTE Of BIOMEDICAL IMAGING & BIOENGINEERING

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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