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Single-Shot Quantitative X-ray Imaging for Interventional Procedures

Award Number: R21EB030080
ORGANIZATION: NATIONAL INSTITUTE Of BIOMEDICAL IMAGING & BIOENGINEERING
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 07/01/2020
PERIOD OF PERFORMANCE END DATE: 03/31/2024

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Single-Shot Quantitative X-ray Imaging for Interventional Procedures - Project Abstract Primary liver cancer, and specifically hepatocellular carcinoma (HCC), is the third most common cause of cancer death worldwide. In patients with intermediate-stage or unresectable HCC, transarterial chemoembolization (TACE) is the most widely used therapy. The success of TACE critically depends on the accurate and complete targeting of the tumor. While x-ray image guidance is routinely used to qualitatively visualize the drug delivery, it currently does not enable quantitative guidance and assessment to determine appropriate delivery endpoints. Therefore, TACE endpoints are highly variable across operators and patients, with poor ability to predict tumor response and patient outcome. To accurately monitor drug accumulation in the tumor, real-time quantification of radiopaque iodine (mixed with the drug prior to delivery) is needed with every x-ray image, a concept we entitle single-shot quantitative imaging (SSQI). SSQI is not currently possible due to several challenges with x-ray imaging, including scatter, multiple overlaying materials, and patient and system motion. We therefore propose robust SSQI enabled by the combination of a primary modulator and a dual-layer detector to quantify iodine areal density in real time. The primary modulator provides scatter correction, while the dual-layer detector provides material-specific images with each exposure. The resulting SSQI system provides iodine quantification and dose-efficient grayscale images that are robust against motion. A key strength of the proposed solution is its simplicity in hardware and software – it is compatible with existing system designs, without introducing new complexities or challenges. Our specific aims include: 1) Build a prototype SSQI system. We will design and construct a primary modulator with optimized material, pitch, and thickness, as well as a dual-layer detector with optimized scintillator thicknesses and filter for quantifying iodine in abdominal imaging. We will also develop a real-time image processing pipeline to convert the modulated dual-layer images into quantitative images. 2) Assess the quantitative imaging accuracy of prototype SSQI system. We will evaluate the material quantification accuracy for iodine tasks representative of TACE using phantoms of various sizes with known amounts of iodine, bone, and other tissue-equivalent materials. We hypothesize that SSQI can achieve accurate iodine quantification and grayscale accuracy, while being dose efficient. The proposed studies will establish a new x-ray imaging paradigm that brings quantitation to every image by simultaneously overcoming several current limitations of x-ray imaging while retaining traditional advantages such as high spatial and temporal resolution and large-area imaging. The simplicity and broad applicability of SSQI to x-ray systems has the potential for widespread adoption as a platform for quantitative imaging.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $0 )
2024	2022	THE LELAND STANFORD JUNIOR UNIVERSITY	450 JANE STANFORD WAY	STANFORD	CA	94305	SANTA CLARA	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	3	9/26/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2022 ( Subtotal = $197,125 )
2022	2022	LELAND STANFORD JUNIOR UNIVERSITY, THE	450 JANE STANFORD WAY	STANFORD	CA	94305	SANTA CLARA	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	3	5/2/2022	NON-COMPETING CONTINUATION	$197,125
														Subtotal = $197,125

Issue Date FY: 2021 ( Subtotal = $248,180 )
2021	2021	LELAND STANFORD JUNIOR UNIVERSITY, THE	450 JANE STANFORD WAY	STANFORD	CA	94305	SANTA CLARA	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	2	5/27/2021	NON-COMPETING CONTINUATION	$248,180
														Subtotal = $248,180

Issue Date FY: 2020 ( Subtotal = $157,700 )
2020	2020	LELAND STANFORD JUNIOR UNIVERSITY, THE	450 JANE STANFORD WAY	STANFORD	CA	94305	SANTA CLARA	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	1	6/19/2020	NEW	$157,700
														Subtotal = $157,700

Grand Total All Awards = $603,005

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Single-Shot Quantitative X-ray Imaging for Interventional Procedures

Award Number: R21EB030080

ORGANIZATION: NATIONAL INSTITUTE Of BIOMEDICAL IMAGING & BIOENGINEERING

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 07/01/2020

PERIOD OF PERFORMANCE END DATE: 03/31/2024

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