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Investigation of the Role of MicroRNAs in Adipose Tissue from People Infected with HIV Who Develop Type 2 Diabetes

Award Number: R21DK145238
ORGANIZATION: NATIONAL INSTITUTE OF DIABETES & DIGESTIVE & KIDNEY DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/05/2025
PERIOD OF PERFORMANCE END DATE: 08/31/2027

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Investigation of the Role of MicroRNAs in Adipose Tissue from People Infected with HIV Who Develop Type 2 Diabetes - People with HIV (PWH) are at increased risk for type 2 diabetes (T2D) due to both disease-related and treatment-related factors. MicroRNAs are regulatory elements of transcription of mRNAs to amino acids and regulate many physiological processes, including in adipose tissue. There is promising but extremely limited evidence for the role of specific microRNAs and their mRNA targets in the dysregulation of adipose tissue related to HIV infection and risk for T2D. We propose to evaluate microRNA expression in adipose tissue from PWH who do and do not have T2D and to investigate whether there are corresponding changes in target mRNA expression that might provide insights about the functional impacts of HIV on adipose tissue and risk for T2D. We will also explore whether circulating microRNAs in plasma may be novel signals for these underlying adipose tissue perturbations and might have clinical implications as biomarkers of risk for T2D in PWH. Knowledge gained from this project has the potential to inform future hypothesis-driven studies into specific molecular targets to diminish the harmful impact of HIV on adipose tissue physiology and risk for T2D and as potential biomarkers to detect latent risk in PWH who are at greatest risk for T2D.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $451,000 )
2025	2025	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94103	SAN FRANCISCO	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	1	9/4/2025	NEW	$451,000
														Subtotal = $451,000

Grand Total All Awards = $451,000

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Investigation of the Role of MicroRNAs in Adipose Tissue from People Infected with HIV Who Develop Type 2 Diabetes

Award Number: R21DK145238

ORGANIZATION: NATIONAL INSTITUTE OF DIABETES & DIGESTIVE & KIDNEY DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/05/2025

PERIOD OF PERFORMANCE END DATE: 08/31/2027

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