Wednesday, September 3, 2025 9/3/2025

Development of a minimally invasive optical biosensor to improve hyperphosphatemia management

Award Number: R21DK134921
ORGANIZATION: NATIONAL INSTITUTE OF DIABETES & DIGESTIVE & KIDNEY DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/01/2023
PERIOD OF PERFORMANCE END DATE: 08/31/2026

Group Awards By:

View Award Description

Development of a minimally invasive optical biosensor to improve hyperphosphatemia management - PROJECT SUMMARY Calcium and phosphate homeostasis is significantly disrupted in advanced chronic kidney disease (CKD) and end-stage kidney disease. Elevated serum phosphate concentration – a condition known as hyperphosphatemia – is a significant cause of cardiovascular morbidity and mortality in this population. Thus, physicians treat these patients with dietary restriction of phosphorus intake and medications that inhibit the absorption of ingested phosphorus. The standard of care is to titrate these interventions to a patient’s serum phosphate concentration, but this level is checked only at monthly intervals, which provides only an infrequent snapshot of a patient’s dynamic condition. Thus, new technology for phosphate monitoring is needed to empower physicians and patients to better manage hyperphosphatemia. The objective of this project is to address this need through the development of an optical biosensor that can be used to non-invasively measure serum phosphate concentration. Aim 1 is focused on biosensor development, which will be approached by designing hydrogel composites encapsulating metalloporphyrin-containing biosensor particles that will transduce phosphate concentration to an optical signal that can be detected through the skin. In vitro testing under simulated physiologic conditions will be performed to optimize the range and sensitivity of the biosensor. Aim 2 encompasses in vivo testing of the biosensor. Testing will be performed in the Col4a3 knockout mouse model of CKD, which exhibits dysregulated calcium and phosphate metabolism and hyperphosphatemia. Biosensor performance will be evaluated by comparison to blood and interstitial fluid measurements of phosphate. If successful, this project will provide a foundation for subsequent testing in a large animal model of CKD and efforts toward clinical translation.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $0 )
2025	2023	TEXAS A&M ENGINEERING EXPERIMENT STATION	3124 TAMU	COLLEGE STATION	TX	77843	BRAZOS	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	1	8/25/2025	NEW	$0
														Subtotal = $0

Issue Date FY: 2024 ( Subtotal = $0 )
2024	2023	TEXAS A&M ENGINEERING EXPERIMENT STATION	3124 TAMU	COLLEGE STATION	TX	77843	BRAZOS	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	1	8/19/2024	NEW	$0
														Subtotal = $0

Issue Date FY: 2023 ( Subtotal = $424,448 )
2023	2023	TEXAS A&M ENGINEERING EXPERIMENT STATION	3124 TAMU	COLLEGE STATION	TX	77843	BRAZOS	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	1	9/8/2023	NEW	$234,378
2023	2023	TEXAS A&M ENGINEERING EXPERIMENT STATION	3124 TAMU	COLLEGE STATION	TX	77843	BRAZOS	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	1	9/1/2023	NEW	$190,070
														Subtotal = $424,448

Grand Total All Awards = $424,448

Top

All Categories

About

Search

Reports

Data Submission

Award Information

Development of a minimally invasive optical biosensor to improve hyperphosphatemia management

Award Number: R21DK134921

ORGANIZATION: NATIONAL INSTITUTE OF DIABETES & DIGESTIVE & KIDNEY DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/01/2023

PERIOD OF PERFORMANCE END DATE: 08/31/2026

Federal Websites

Department of Health & Human Services

HHS Operating Divisions

HHS Staff Divisions

Download A Document Viewer