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Molecular determinants of Streptococcus gordonii response to shear forces

Award Number: R21DE035117
ORGANIZATION: NATIONAL INSTITUTE OF DENTAL AND CRANIOFACIAL RESEARCH
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 07/07/2026
PERIOD OF PERFORMANCE END DATE: 07/06/2028

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Molecular determinants of Streptococcus gordonii response to shear forces - Abstract Fluid flow is present in multiple sites in the human body, including the oral cavity, where it is generated through the movement of saliva during mastication, conversation, and other jaw motions. The shear forces generated by fluid flow significantly affect biofilm formation and maintenance; however, the cellular mechanisms utilized by microbes to sense and adapt to fluid flow are broadly not understood. We must better understand how bacteria sense and adapt to the mechanical forces generated by fluid flow (mechanosensing), as it could significantly enhance our ability to treat or prevent numerous biofilm-associated diseases. Our proposed studies will investigate how fluid flow is sensed by Streptococcus gordonii and how it affects its biofilm. As a pioneer colonizer of the oral cavity, S. gordonii binds directly to saliva-coated surfaces, where it helps integrate other oral microorganisms into the dental plaque biofilm community. In the bloodstream, S. gordonii can travel to the heart, forming biofilms on damaged heart valves and causing infective endocarditis. In this proposal, we aim to broaden our understanding of the impact of fluid shear forces on oral bacteria by (i) identifying genes involved in S. gordonii’s ability to adapt to forces generated by fluid flow and (ii) evaluating S. gordonii's gene expression in real-time in response to different shear forces using a previously developed microfluidics system.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $411,775 )
2026	2026	UNIVERSITY OF FLORIDA	1523 UNION RD RM 207	GAINESVILLE	FL	32611	ALACHUA	USA	Oral Diseases and Disorders Research	000	1	7/8/2026	NEW	$411,775
														Subtotal = $411,775

Grand Total All Awards = $411,775

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Molecular determinants of Streptococcus gordonii response to shear forces

Award Number: R21DE035117

ORGANIZATION: NATIONAL INSTITUTE OF DENTAL AND CRANIOFACIAL RESEARCH

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 07/07/2026

PERIOD OF PERFORMANCE END DATE: 07/06/2028

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