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SARS-CoV-2 tropism and immunomodulation in salivary gland

Award Number: R21DE033795
ORGANIZATION: NATIONAL INSTITUTE OF DENTAL AND CRANIOFACIAL RESEARCH
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 06/17/2025
PERIOD OF PERFORMANCE END DATE: 06/16/2027

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SARS-CoV-2 tropism and immunomodulation in salivary gland - Project Summary/Abstract SARS-CoV-2 has been detected in a variety of human tissues, including the salivary gland. While its behavior in the respiratory tract has been widely studied, relatively little is known about how this virus interacts with oral tissues and the local immune environment. The salivary gland may serve as a unique site of viral presence and immunological modulation, particularly through pathways involving non-classical major histocompatibility complex (MHC) class I molecules. This project aims to investigate fundamental aspects of the innate immune response to SARS-CoV-2 within the salivary gland, with a focus on the molecular interactions between virus- or host-derived peptides and components of the mucosal immune system. In particular, we will explore how antigen presentation mechanisms may shape or reflect local immune activity in this tissue. Identifying such mechanisms will advance our understanding of tissue-specific immune regulation and viral tropism. The proposed research is designed to clarify basic molecular and cellular processes that underlie host-pathogen interactions in the oral cavity. By studying immunological dynamics in the salivary gland, this work will contribute to a framework for understanding mucosal immunity and may reveal foundational principles of immune surveillance in non-respiratory tissues.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $401,500 )
2025	2025	LOUISIANA STATE UNIVERSITY	1501 KINGS HWY	SHREVEPORT	LA	71103	CADDO	USA	Oral Diseases and Disorders Research	000	1	6/17/2025	NEW	$401,500
														Subtotal = $401,500

Grand Total All Awards = $401,500

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SARS-CoV-2 tropism and immunomodulation in salivary gland

Award Number: R21DE033795

ORGANIZATION: NATIONAL INSTITUTE OF DENTAL AND CRANIOFACIAL RESEARCH

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 06/17/2025

PERIOD OF PERFORMANCE END DATE: 06/16/2027

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