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DEVELOPMENT OF A SMARTPHONE-BASED INFRARED-FLUORESCENCEIMAGING INTRAORAL DEVICE (SMART-IR-ID) FOR DENTIST-GUIDED REALTIME SELF-MONITORING OF PERIODONTAL DISEASE

Award Number: R21DE029152
ORGANIZATION: NATIONAL INSTITUTE OF DENTAL AND CRANIOFACIAL RESEARCH
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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DEVELOPMENT OF A SMARTPHONE-BASED INFRARED-FLUORESCENCEIMAGING INTRAORAL DEVICE (SMART-IR-ID) FOR DENTIST-GUIDED REALTIME SELF-MONITORING OF PERIODONTAL DISEASE - PROJECT SUMMARY: Periodontal disease (PD), a common infectious/inflammatory disease, is preventable for much of the population by early detection and treatment; however, the high prevalence of PD (47% of Americans adults having periodontitis) makes it a public health concern, having a socio-economic burden of up to $442 billion each year. PD is typically diagnosed by the dental hygienist, dentist, or periodontist tracking alveolar bone height and gingival height through intraoral radiographs (X-rays) and periodontal probing. Dental X-rays are the most reliable intraoral imaging tool for identifying tooth/cavity conditions and bone lesions; however, dental X-rays cannot detect early periodontal lesions and visualize the topography of periodontal pocket (PP). Also, dental X-rays cannot be used as a routine screening tool to exam the progression of PD during the follow-up period because its ionizing radiation poses health risks and concerns. Periodontal probing is, therefore, the standard approach for complete PD diagnosis and follow-up checkups. The structural status of the periodontal soft tissues can be estimated by pocket depth measurement, gingival bleeding, and visual signs of gingival inflammation (redness and swelling). To the best of our knowledge, there is still no reliable technology that can provide 3D structure information of the PP and inflamed gingiva during PD progression. The objective of this proposal is to develop a smartphone-based infrared-fluorescence-imaging intraoral device (Smart-IR-ID) to measure the 3D structure of the PP and gingival inflammation for dentist-guided self-exam and tracking of PD. We propose to address this objective through 2 specific aims: 1) To investigate the infrared (IR) fluorescence imaging approach to develop IR intraoral devices that can precisely deliver and release the minimal required dosage of imaging agents into inflamed gingiva and PP; and 2) To develop the dual-module optical sensors and smartphone-based 3D modeling system for digital 3D IR-imaging and reporting the 3D measurements of PP and gingival inflammation. Our proposed project is innovative as a smartphone-based intraoral IR fluorescence imaging system in visualizing the 3D structure of PP and infected soft tissue of periodontium is a completely underexplored research area. The expected outcome of this work is to provide the pioneering prototype for our precision medicine-based intraoral imaging device integrated into a mHealth platform. Smart- IR-ID, in particular, opens the possibility of combining imaging and therapeutic capabilities at the next stage. Our project is significant because this research will develop a platform-specific model that can be linked to other intraoral diagnostic and therapeutic devices, transforming PD management from on-site clinical care in clinic facilities to dentist-guided self-care at the point-of-need.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = -$7,472 )
2025	2020	THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK	4400 VESTAL PKWY E	BINGHAMTON	NY	13902	BROOME	USA	Oral Diseases and Disorders Research	000	3	1/30/2025	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	-$7,472
														Subtotal = -$7,472

Issue Date FY: 2023 ( Subtotal = $0 )
2023	2020	RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK, THE	4400 VESTAL PKWY E	BINGHAMTON	NY	13902	BROOME	USA	Oral Diseases and Disorders Research	000	3	8/24/2023	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$0
														Subtotal = $0

Issue Date FY: 2022 ( Subtotal = $0 )
2022	2020	RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK, THE	4400 VESTAL PKWY E	BINGHAMTON	NY	13902	BROOME	USA	Oral Diseases and Disorders Research	000	3	10/8/2021	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$0
2022	2020	RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK, THE	4400 VESTAL PKWY E	BINGHAMTON	NY	13902	BROOME	USA	Oral Diseases and Disorders Research	001	3	8/26/2022	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$0
														Subtotal = $0

Issue Date FY: 2021 ( Subtotal = $0 )
2021	2020	WASHINGTON STATE UNIVERSITY	240 FRENCH ADMINISTRATION BLDG	PULLMAN	WA	99164	WHITMAN	USA	Oral Diseases and Disorders Research	000	2	3/15/2021	NON-COMPETING CONTINUATION	-$222,582
2021	2020	RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK, THE	4400 VESTAL PKWY E	BINGHAMTON	NY	13902	BROOME	USA	Oral Diseases and Disorders Research	001	3	3/23/2021	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$222,582
2021	2020	RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK, THE	4400 VESTAL PKWY E	BINGHAMTON	NY	13902	BROOME	USA	Oral Diseases and Disorders Research	003	3	7/17/2021	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$81,430
2021	2019	WASHINGTON STATE UNIVERSITY	240 FRENCH ADMINISTRATION BLDG	PULLMAN	WA	99164	WHITMAN	USA	Oral Diseases and Disorders Research	002	1	7/17/2021	NEW	-$81,430
														Subtotal = $0

Issue Date FY: 2020 ( Subtotal = $222,582 )
2020	2020	WASHINGTON STATE UNIVERSITY	240 FRENCH ADMINISTRATION BLDG	PULLMAN	WA	99164	WHITMAN	USA	Oral Diseases and Disorders Research	000	2	8/21/2020	NON-COMPETING CONTINUATION	$222,582
														Subtotal = $222,582

Issue Date FY: 2019 ( Subtotal = $184,582 )
2019	2019	WASHINGTON STATE UNIVERSITY	240 FRENCH ADMINISTRATION BLDG	PULLMAN	WA	99164	WHITMAN	USA	Oral Diseases and Disorders Research	000	1	9/16/2019	NEW	$184,582
														Subtotal = $184,582

Grand Total All Awards = $399,692

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DEVELOPMENT OF A SMARTPHONE-BASED INFRARED-FLUORESCENCEIMAGING INTRAORAL DEVICE (SMART-IR-ID) FOR DENTIST-GUIDED REALTIME SELF-MONITORING OF PERIODONTAL DISEASE

Award Number: R21DE029152

ORGANIZATION: NATIONAL INSTITUTE OF DENTAL AND CRANIOFACIAL RESEARCH

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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