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Dental and Craniofacial Effects of Intrauterine Zika Virus Infection

Award Number: R21DE027235
ORGANIZATION: NATIONAL INSTITUTE OF DENTAL AND CRANIOFACIAL RESEARCH
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 04/22/2019
PERIOD OF PERFORMANCE END DATE: 09/30/2020

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Dental and Craniofacial Effects of Intrauterine Zika Virus Infection - Project Summary/Abstract: Zika has been demonstrated to affect the development of the fetus. To date, a direct association between intrauterine Zika infection and severe congenital malformations, such as microcephaly, has been recognized as a public health emergency worldwide. In spite of multiple international efforts, there is still a significant gap in the state of scientific knowledge regarding the extent of the effects of intrauterine Zika exposure at different periods of gestation. Given that transmission of the virus does not require vector transmission, the need to understand the effects of intrauterine Zika exposure on fetal development is critical. Evidence of the causal role of congenintal Zika virus infection is clear as the virus has been identified in the brains of affected fetuses. Given that 30% of pregnant women in Puerto Rico may have asymptomatic Zika virus infections. For fetus’ born to these women, we do not know that actual rate of impact of the virus on fetal craniofacial and dental development. The increasing understanding regarding congenital Zika point to a range of anomalies, but the effects on craniofacial and dental development remains undefined. We also do not know what other conditions may alter the virulence of the Zika virus. There is strong evidence that maternal oral health status is associated to adverse pregnancy outcomes, but the role maternal periodontal disease on the health outcomes in Zika-exposed mothers is currently unknown and unexplored. The role of other aspects of maternal and infant oral health in the craniofacial phenotype and oromotor function of infants born to Zika-affected women requires further study. It is the main objective of this study to characterize the outcome of maternal Zika virus infection on craniofacial skeletal and dental phenotype in infants with or without microcephaly at birth. Clinical, radiographic and 3dMD Facial Surface Imaging techniques will be used to develop a vastly documented craniofacial phenotype of a sample of affected infants; their assessments will be compared to matched controls. Data from oral health examinations and biological samples from both the mother and the infant up to 12 months post-partum will be collected. These data will allow the examination of the concomitant aspects of oral health that may impact the capacity of the virus to cause an adverse effect in the infant. The infant’s oromotor function assessment will be completed at 6 and 12 months. Findings will be discussed among members of the craniofacial team in blinded fashion to be able to determine whether there is an effect of congenital Zika infection on craniofacial and dental development.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = -$21,969 )
2026	2019	UNIVERSITY OF PUERTO RICO MEDICAL SCIENCES CAMPUS	B622 MAIN BUILDING FLR 6	SAN JUAN	PR	00935	SAN JUAN	USA	Extramural Research Restoration Program: Hurricanes Harvey, Maria, and Irma – non-construction	000	2	10/1/2025	SUPPLEMENT FOR EXPANSION	-$21,969
														Subtotal = -$21,969

Issue Date FY: 2022 ( Subtotal = -$4 )
2022	2019	UNIVERSITY OF PUERTO RICO MEDICAL SCIENCES CAMPUS	MAIN BLDG FLR 6 B-622	SAN JUAN	PR	00935	SAN JUAN	USA	Oral Diseases and Disorders Research	000	2	1/18/2022	SUPPLEMENT FOR EXPANSION	-$4
														Subtotal = -$4

Issue Date FY: 2021 ( Subtotal = $0 )
2021	2019	UNIVERSITY OF PUERTO RICO MEDICAL SCIENCES CAMPUS	MAIN BLDG FLR 6 B-622	SAN JUAN	PR	00935	SAN JUAN	USA	Extramural Research Restoration Program: Hurricanes Harvey, Maria, and Irma – non-construction	000	2	5/21/2021	SUPPLEMENT FOR EXPANSION	$0
														Subtotal = $0

Issue Date FY: 2020 ( Subtotal = $0 )
2020	2019	UNIVERSITY OF PUERTO RICO MEDICAL SCIENCES CAMPUS	MAIN BLDG FLR 6 B-622	SAN JUAN	PR	00935	SAN JUAN	USA	Oral Diseases and Disorders Research	002	2	9/14/2020	SUPPLEMENT FOR EXPANSION	$0
2020	2018	UNIVERSITY OF PUERTO RICO MEDICAL SCIENCES CAMPUS	MAIN BLDG FLR 6 B-622	SAN JUAN	PR	00935	SAN JUAN	USA	Oral Diseases and Disorders Research	000	2	9/14/2020	NON-COMPETING CONTINUATION	$0
2020	2018	UNIVERSITY OF PUERTO RICO MEDICAL SCIENCES CAMPUS	MAIN BLDG FLR 6 B-622	SAN JUAN	PR	00935	SAN JUAN	USA	Oral Diseases and Disorders Research	001	2	9/14/2020	SUPPLEMENT FOR EXPANSION	$0
														Subtotal = $0

Issue Date FY: 2019 ( Subtotal = $270,836 )
2019	2019	UNIVERSITY OF PUERTO RICO MEDICAL SCIENCES CAMPUS	MAIN BLDG FLR 6 B-622	SAN JUAN	PR	00935	SAN JUAN	USA	Oral Diseases and Disorders Research	001	2	7/26/2019	SUPPLEMENT FOR EXPANSION	$67,841
2019	2019	UNIVERSITY OF PUERTO RICO MEDICAL SCIENCES CAMPUS	MAIN BLDG FLR 6 B-622	SAN JUAN	PR	00935	SAN JUAN	USA	Extramural Research Restoration Program: Hurricanes Harvey, Maria, and Irma – non-construction	000	2	4/18/2019	SUPPLEMENT FOR EXPANSION	$202,995
														Subtotal = $270,836

Issue Date FY: 2018 ( Subtotal = $315,714 )
2018	2018	UNIVERSITY OF PUERTO RICO MEDICAL SCIENCES CAMPUS	MAIN BLDG FLR 6 B-622	SAN JUAN	PR	00935	SAN JUAN	USA	Oral Diseases and Disorders Research	000	2	8/24/2018	NON-COMPETING CONTINUATION	$202,995
2018	2018	UNIVERSITY OF PUERTO RICO MEDICAL SCIENCES CAMPUS	MAIN BLDG FLR 6 B-622	SAN JUAN	PR	00935	SAN JUAN	USA	Oral Diseases and Disorders Research	001	2	8/31/2018	SUPPLEMENT FOR EXPANSION	$112,719
														Subtotal = $315,714

Issue Date FY: 2017 ( Subtotal = $251,882 )
2017	2017	UNIVERSITY OF PUERTO RICO MEDICAL SCIENCES CAMPUS	MAIN BLDG FLR 6 B-622	SAN JUAN	PR	00935	SAN JUAN	USA	Oral Diseases and Disorders Research	000	1	8/21/2017	NEW	$251,882
														Subtotal = $251,882

Grand Total All Awards = $816,459

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Dental and Craniofacial Effects of Intrauterine Zika Virus Infection

Award Number: R21DE027235

ORGANIZATION: NATIONAL INSTITUTE OF DENTAL AND CRANIOFACIAL RESEARCH

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 04/22/2019

PERIOD OF PERFORMANCE END DATE: 09/30/2020

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