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Predicting Late Talkers in Infants who are at Elevated Familial Likelihood for Autism

Award Number: R21DC022754
ORGANIZATION: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 08/01/2025
PERIOD OF PERFORMANCE END DATE: 07/31/2027

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Predicting Late Talkers in Infants who are at Elevated Familial Likelihood for Autism - ABSTRACT Predicting Late Talkers in Infants who are at Elevated Familial Likelihood for Autism Autistic children are late to say their first word, and these early challenges persist with over 70% of autistic preschoolers having language impairment. Siblings of autistic children unaffected by autism themselves are at a 4-5-fold increased risk of developing language challenges. The field lacks screening tools with strong predictive power to identify late talking autistic children during the birth-to-three early intervention period. The proposed project makes significant steps towards early identification of language impairment and understanding the developmental sequelae of language in autistic toddlers by leveraging data from the Baby Sibling Research Consortium database, the largest collection of language data of infants who develop autism. Aim 1 of the proposed study is create a normative model sensitive to the heterogeneity of autistic language development using summary-level data from the MacArthur-Bates Communicative Development Inventories (CDI). This model will then be used to predict late talkers. The normative modeling framework quantifies individual differences in scores, flagging individuals for further follow up. This framework moves away from the limitations of simple “case- control” designs by allowing for the heterogeneity that is inherent to developmental disorders. We will make our normative model publicly available, to be used by investigators interested in samples that tend to be smaller in size, increasing the significance and


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $448,335 )
2025	2025	REGENTS OF THE UNIVERSITY OF MINNESOTA	2221 UNIVERSITY AVE SE STE 100	MINNEAPOLIS	MN	55414	HENNEPIN	USA	Research Related to Deafness and Communication Disorders	000	1	7/30/2025	NEW	$448,335
														Subtotal = $448,335

Grand Total All Awards = $448,335

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Predicting Late Talkers in Infants who are at Elevated Familial Likelihood for Autism

Award Number: R21DC022754

ORGANIZATION: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 08/01/2025

PERIOD OF PERFORMANCE END DATE: 07/31/2027

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