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Neural Mechanisms underlying Obesity-induced Taste Dysfunction

Award Number: R21DC022726
ORGANIZATION: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/03/2025
PERIOD OF PERFORMANCE END DATE: 08/31/2027

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Neural Mechanisms underlying Obesity-induced Taste Dysfunction - PROJECT SUMMARY A key driver of the obesity epidemic is the excessive consumption of highly palatable, calorie-rich foods. Obesity, in turn, leads to substantial alterations in taste sensitivity and food preferences, perpetuating the obese state. However, the neurobiological underpinnings of the interaction between obesity and taste sensation remain largely uncharted. The overall objective of this application is to determine how the brainstem neurons that convey taste information are impacted by obesity. To achieve this, we propose studies to identify obesity-dependent changes to taste neurons at the circuit-, cellular- and molecular-level. In the long-term, we envision that these studies will reveal platforms for therapeutic intervention aimed at disrupting the self-perpetuating cycle of overconsumption in obesity.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $434,558 )
2025	2025	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	Research Related to Deafness and Communication Disorders	000	1	9/3/2025	NEW	$434,558
														Subtotal = $434,558

Grand Total All Awards = $434,558

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Neural Mechanisms underlying Obesity-induced Taste Dysfunction

Award Number: R21DC022726

ORGANIZATION: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/03/2025

PERIOD OF PERFORMANCE END DATE: 08/31/2027

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