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The Influence of Vocal Loading Upon the Healing of Experimental Vocal Fold Injury

Award Number: R21DC019992
ORGANIZATION: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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Project Summary The development and maintenance of a speaking and singing fundamental frequency, while also achieving vocal clarity throughout life, are important public health concerns. Symptoms of dysphonia are among the most common communication disorders. Currently there is no treatment to restore a native vocal fold lamina propria composition or laryngeal movements after injury. Research is limited because there is no in vivo model for larynx injuries that express a vocal behavior that can serve as a reliable phenotypic marker. In general, an animal model can benefit research if its behavior can serve as marker for the onset or the time-course of a pathology affecting a complex behavior. Specifically, the availability of an animal model that combines experimental and genetic accessibility with important similarities to human voice production could allow stronger inferences. Here we propose (1) to quantify key anatomical features of the vocal organ during postnatal developmental in a new model, and (2) to describe the time-course of wound healing after experimental vocal fold injury in a vocal dose- dependent fashion. Results will be integrated in a computational vocal fold model. Completion of this work will provide the field with a new mouse model for the study of vocal disease mechanisms and therapeutic development. It will also inform the role of vocal occupancy on the healing process of vocal folds.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2023 ( Subtotal = $187,500 )
2023	2023	MIDWESTERN UNIVERSITY	19555 N. 59TH AVE,	GLENDALE	AZ	85308	MARICOPA	USA	Research Related to Deafness and Communication Disorders	000	2	7/13/2023	NON-COMPETING CONTINUATION	$187,500
														Subtotal = $187,500

Issue Date FY: 2022 ( Subtotal = $217,000 )
2022	2022	MIDWESTERN UNIVERSITY	19555 N 59TH AVE	GLENDALE	AZ	85308	MARICOPA	USA	Research Related to Deafness and Communication Disorders	000	1	8/1/2022	NEW	$217,000
														Subtotal = $217,000

Grand Total All Awards = $404,500

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The Influence of Vocal Loading Upon the Healing of Experimental Vocal Fold Injury

Award Number: R21DC019992

ORGANIZATION: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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