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Optimizing MOUD Expansion in Maryland Using Data-Driven Implementation Strategies

Award Number: R21DA066724
ORGANIZATION: NATIONAL INSTITUTE ON DRUG ABUSE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/01/2026
PERIOD OF PERFORMANCE END DATE: 08/31/2028

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Optimizing MOUD Expansion in Maryland Using Data-Driven Implementation Strategies - PROJECT SUMMARY/ABSTRACT Substance use disorders (SUDs) affected 48.4 million Americans in 2024, including 4.8 million with Opioid Use Disorder (OUD). Despite strong evidence that medications for OUD (MOUD) reduce overdose risk, many Americans do not receive needed MOUD. Geographic distribution of providers, transportation barriers, and limited provider readiness contribute to this gap, especially in rural areas. Proven implementation strategies— including mobile MOUD services, telehealth-delivered MOUD (teleMOUD), and provider training and technical assistance (TA)—can expand access, yet they are rarely deployed using systematic, data-driven approaches. This R21 uses existing administrative, geospatial, and economic data to prospectively identify opportunities to deploy MOUD implementation strategies across Maryland. Aim 1 constructs a MOUD Access Index that integrates OUD prevalence, provider capacity, spatial accessibility, and contextual factors to model need for and access to MOUD. Aim 2 applies spatial optimization modeling to optimize the use of the three identified implementation strategies across Maryland. These strategies will be optimized under real world constraints to maximize population coverage and minimize travel burden for patients. Aim 3 evaluates the incremental cost- effectiveness of these geo-optimized strategies relative to current service distribution, reporting cost per MOUD initiation, overdose averted, and QALY gained. By linking geospatial modeling, implementation science, and cost-effectiveness modeling, this study will produce actionable guidance to inform MOUD expansion. The findings will advance implementation science and addiction health services research by integrating spatial analytics and economic evaluation into prospective implementation strategy selection. Findings will support scalable MOUD delivery models, ultimately contributing to reduced overdose mortality and enhanced treatment retention across underserved communities.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $444,801 )
2026	2026	UNIVERSITY OF MARYLAND, COLLEGE PARK	3112 LEE BUILDING	COLLEGE PARK	MD	20742	PRINCE GEORGES	USA	Drug Use and Addiction Research Programs	000	1	8/21/2026	NEW	$444,801
														Subtotal = $444,801

Grand Total All Awards = $444,801

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Optimizing MOUD Expansion in Maryland Using Data-Driven Implementation Strategies

Award Number: R21DA066724

ORGANIZATION: NATIONAL INSTITUTE ON DRUG ABUSE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/01/2026

PERIOD OF PERFORMANCE END DATE: 08/31/2028

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