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The non-fatal overdose crisis: Sex and gender differences in healthcare utilization and health outcomes of people living with and without HIV between 2012 and 2020

Award Number: R21DA057058
ORGANIZATION: NATIONAL INSTITUTE ON DRUG ABUSE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 07/01/2023
PERIOD OF PERFORMANCE END DATE: 06/30/2025

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The non-fatal overdose crisis: Sex and gender differences in healthcare utilization and health outcomes of people living with and without HIV between 2012 and 2020 - PROJECT SUMMARY/ABSTRACT The overdose (OD) crisis continues to devastate communities across North America. Despite 90% of paramedic- attended ODs in British Columbia (BC), Canada being non-fatal, much of the research has focused on fatal ODs. While men account for over 70% of fatal ODs, there is evidence of a more balanced distribution of men and women experiencing non-fatal ODs (NFODs); further, women have higher mortality rates in the year following an NFOD. People living with HIV (PLHIV) are disproportionately affected by the OD crisis and are at increased risk of fatal ODs, yet little is known about the longer-term impacts of NFODs on PLHIV in terms of adverse health outcomes and healthcare utilization (HCU). Considering the increasingly high rates of NFODs, gendered differences in mortality following an NFOD, and knowledge gaps concerning health outcomes following an NFOD, this proposal seeks funding to investigate the role of sex, gender, and HIV status in differential NFOD outcomes. BC’s universal healthcare system and data centralization enabled the Comparative Outcomes And Service Utilization Trends (COAST) Study, a population-based longitudinal cohort comprised of linked administrative health datasets on all known adult PLHIV and a 10% random sample of the general population in BC. Using COAST, we aim to: (1) Generate estimates for the incidence rates of fatal and nonfatal ODs among people living with and without HIV (2012-2020) in BC; (2) Assess and compare changes in health care utilization, chronic comorbidity, and mortality among people living with and without HIV who experienced an NFOD, modified by sex and gender; and (3) Assess and compare changes in HIV treatment outcomes in people living with HIV who experienced an NFOD, modified by sex and gender. This project will also involve the development of a Community Advisory Board (CAB) for proposed and future projects. The CAB will provide guidance to ensure research soundness and relevance to the community throughout the research and knowledge mobilization processes. Our collaborative research will be an opportunity to explore other research possibilities initiated by the CAB as important for women and gender minorities living with and without HIV who are affected by the OD crisis. In response to the National Institute on Drug Abuse Notice of Special Interest NOT-DA- 21-021 to advance research specific to women and other underrepresented populations including gender minorities, this proposal will inform future CAB-led cycles of inquiry and analysis amongst our team to answer relevant research questions and address the identified needs of cisgender women and gender minorities living with and without HIV affected by the OD crisis.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = -$2 )
2026	2024	SIMON FRASER UNIVERSITY	8888 UNIVERSITY DRIVE	BURNABY	BC			CAN	Drug Use and Addiction Research Programs	000	2	12/15/2025	NON-COMPETING CONTINUATION	-$2
														Subtotal = -$2

Issue Date FY: 2024 ( Subtotal = $154,703 )
2024	2024	SIMON FRASER UNIVERSITY	8888 UNIVERSITY DRIVE	BURNABY	BC			CAN	Drug Use and Addiction Research Programs	000	2	6/12/2024	NON-COMPETING CONTINUATION	$154,703
														Subtotal = $154,703

Issue Date FY: 2023 ( Subtotal = $136,788 )
2023	2023	SIMON FRASER UNIVERSITY	8888 UNIVERSITY DRIVE	BURNABY	BC			CAN	Drug Use and Addiction Research Programs	000	1	6/30/2023	NEW	$136,788
														Subtotal = $136,788

Grand Total All Awards = $291,489

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The non-fatal overdose crisis: Sex and gender differences in healthcare utilization and health outcomes of people living with and without HIV between 2012 and 2020

Award Number: R21DA057058

ORGANIZATION: NATIONAL INSTITUTE ON DRUG ABUSE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 07/01/2023

PERIOD OF PERFORMANCE END DATE: 06/30/2025

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