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Electronic cigarette use during pregnancy and the impact on newborn metabolic profile and perinatal health outcomes

Award Number: R21DA052026
ORGANIZATION: NATIONAL INSTITUTE ON DRUG ABUSE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 05/01/2021
PERIOD OF PERFORMANCE END DATE: 04/30/2024

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Electronic cigarette use during pregnancy and the impact on newborn metabolic profile and perinatal health outcomes - PROJECT ABSTRACT Electronic cigarettes (e-cigarettes), since their first introduction in the world market in 2004, have been advertised as a healthier alternative and a smoking cessation aid to existing tobacco products. has youth E-cigarette use been increased dramatically in the recent years, becoming the most commonly used smoking product in and young adults since 2014. Itis particularly appealing to pregnant women smokers who are motivated to change their smoking habits and to improve their and their fetus' health. However, the potential adverse effects of e-cigarettes as shown in the recent outbreak, whether it poses an increased risk to women and their developing fetus, is unknown. The overarching objectives of the study are 1) to determine the longitudinal pattern of women's smoking from preconception to perinatal period and over time, 2) to determine the association between pregnancy e-cigarette use and pregnancy, perinatal, and infant related adverse outcomes, and 3) to determine the association between pregnancy e-cigarette use and metabolic profile measured at birth. We propose to conduct a surveillance study of women who gave live births between 2016- 2018 and participated in the Centers for Disease Control and Prevention (CDC) initiated Pregnancy Risk Assessment Monitoring System (PRAMS) survey. Detailed smoking information, including conventional cigarette and e-cigarette use during preconception, 3rd trimester of pregnancy, and post-delivery have been collected. We will further link PRAMS study of women from Tennessee and Iowa to newborn metabolic screening (NBS) program data to identify and validate metabolic profile measured at birth that are associated with secondhand in utero e-cigarette and conventional cigarette exposure. Our proposed study will address important questions and will be of significant public health importance. It will provide much needed information about pregnancy e-cigarette use. Results will certainly inform policy and drive public health initiative, providing evidence for targeted maternal-fetal interventions in smoking cessation and in mitigating adverse effects of smoking on outcomes. It may further provide insight in addressing recent outbreak of e-cigarette, or vaping, product use associated lung injury (EVALI).


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = -$26,128 )
2024	2022	VANDERBILT UNIVERSITY MEDICAL CENTER	1161 21ST AVE S STE D3300 MCN	NASHVILLE	TN	37232	DAVIDSON	USA	Family Smoking Prevention and Tobacco Control Act Regulatory Research	000	2	8/27/2024	NON-COMPETING CONTINUATION	-$26,128
														Subtotal = -$26,128

Issue Date FY: 2023 ( Subtotal = $0 )
2023	2022	VANDERBILT UNIVERSITY MEDICAL CENTER	1161 21ST AVE S STE D3300 MCN	NASHVILLE	TN	37232	DAVIDSON	USA	Family Smoking Prevention and Tobacco Control Act Regulatory Research	000	2	10/17/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2022 ( Subtotal = $241,163 )
2022	2022	VANDERBILT UNIVERSITY MEDICAL CENTER	1161 21ST AVE S STE D3300 MCN	NASHVILLE	TN	37232	DAVIDSON	USA	Family Smoking Prevention and Tobacco Control Act Regulatory Research	000	2	4/12/2022	NON-COMPETING CONTINUATION	$241,163
														Subtotal = $241,163

Issue Date FY: 2021 ( Subtotal = $216,724 )
2021	2021	VANDERBILT UNIVERSITY MEDICAL CENTER	1161 21ST AVE S STE D3300 MCN	NASHVILLE	TN	37232	DAVIDSON	USA	Family Smoking Prevention and Tobacco Control Act Regulatory Research	000	1	4/20/2021	NEW	$216,724
														Subtotal = $216,724

Grand Total All Awards = $431,759

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Electronic cigarette use during pregnancy and the impact on newborn metabolic profile and perinatal health outcomes

Award Number: R21DA052026

ORGANIZATION: NATIONAL INSTITUTE ON DRUG ABUSE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 05/01/2021

PERIOD OF PERFORMANCE END DATE: 04/30/2024

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