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Paramedic-Administered Buprenorphine as a Bridge to Medication-Assisted Treatment

Award Number: R21DA048086
ORGANIZATION: NATIONAL INSTITUTE ON DRUG ABUSE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 01/15/2019
PERIOD OF PERFORMANCE END DATE: 12/31/2022

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Paramedic-Administered Buprenorphine as a Bridge to Medication-Assisted Treatment - Abstract Opioid use disorder is considered a chronic and life-threatening condition that affects at least 2.5 million people in the United. States. To reduce opioid overdose deaths and begin a bridge to treatment among people with opioid overdose disorder, the Medical Director of Emergency Services of Forsyth County, North Carolina has just signed a protocol allowing specially trained community paramedics to administer buprenorphine for up to seven days as a bridge to Medication Assisted Treatment (MAT). The paramedics will offer this medication to opioid overdose survivors (OOS) beginning immediately following reversal, and without requiring transport to an emergency department. This cutting edge and innovative preventive intervention is intended to meet OOS where they are by providing an initial dose of buprenorphine for withdrawal relief and support for MAT initiation. At present, we do not know whether OOS are willing to begin this regimen at this vulnerable time. Our study’s purpose is to examine the extent to which OOS consent to accept paramedic-prescribed buprenorphine administered immediately following reversal. We will also examine whether the presence of a community- based peer navigator at the scene of an overdose reversal, in addition to a paramedic, increases OOS’ acceptance of buprenorphine. The peer navigator’s role will be to provide support, encouragement, and education concerning the benefits of buprenorphine as a bridge to MAT. Our study will clarify whether a buprenorphine regimen as a bridge to MAT can successfully be introduced immediately following a reversal, or whether the invitation should be delayed, as some believe, until a later time. We will also investigate the added value of peer navigators as a means to encourage OOS to begin buprenorphine, as well as OOS’ characteristics associated with the acceptance or refusal of the medication. We will analyze community paramedic data collected at the time of reversal to calculate the proportion of persons who accept buprenorphine and whether acceptance rates vary by the presence of a peer navigator. This observational study is time-sensitive as the findings of this unique opportunity will yield invaluable information concerning this novel strategy to prevent opioid overdoses and facilitate OOS’ entry into MAT.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $0 )
2024	2020	PACIFIC INSTITUTE FOR RESEARCH & EVALUATION	4061 POWDER MILL RD	BELTSVILLE	MD	20705	PRINCE GEORGES	USA	Drug Use and Addiction Research Programs	000	2	10/18/2023	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2022 ( Subtotal = $0 )
2022	2020	PACIFIC INSTITUTE FOR RESEARCH AND EVALUATION	4061 POWDER MILL RD STE 350	BELTSVILLE	MD	20705	PRINCE GEORGES	USA	Drug Use and Addiction Research Programs	000	2	12/7/2021	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2020 ( Subtotal = $196,487 )
2020	2020	PACIFIC INSTITUTE FOR RESEARCH AND EVALUATION	11720 BELTSVILLE DR STE 900	BELTSVILLE	MD	20705	PRINCE GEORGES	USA	Drug Use and Addiction Research Programs	000	2	12/23/2019	NON-COMPETING CONTINUATION	$176,837
2020	2020	PACIFIC INSTITUTE FOR RESEARCH AND EVALUATION	11720 BELTSVILLE DR STE 900	BELTSVILLE	MD	20705	PRINCE GEORGES	USA	Drug Use and Addiction Research Programs	001	2	2/20/2020	NON-COMPETING CONTINUATION	$19,650
														Subtotal = $196,487

Issue Date FY: 2019 ( Subtotal = $238,489 )
2019	2019	PACIFIC INSTITUTE FOR RESEARCH AND EVALUATION	11720 BELTSVILLE DR STE 900	BELTSVILLE	MD	20705	PRINCE GEORGES	USA	Drug Use and Addiction Research Programs	000	1	1/10/2019	NEW	$238,489
														Subtotal = $238,489

Grand Total All Awards = $434,976

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Paramedic-Administered Buprenorphine as a Bridge to Medication-Assisted Treatment

Award Number: R21DA048086

ORGANIZATION: NATIONAL INSTITUTE ON DRUG ABUSE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 01/15/2019

PERIOD OF PERFORMANCE END DATE: 12/31/2022

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