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A BCR transgenic mouse model to study glycan-specific B cells

Award Number: R21CA297692
ORGANIZATION: NATIONAL CANCER INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 02/01/2025
PERIOD OF PERFORMANCE END DATE: 01/31/2027

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A BCR transgenic mouse model to study glycan-specific B cells - SUMMARY Tumor associated carbohydrate antigens (TACAs) are aberrant glycosylation products that are expressed on cancer cells but absent on most normal cells. Their expression is typically associated with metastasis, poor prognosis, and reduced overall survival. Our understanding of the mechanisms regulating antibody responses to TACAs is very limited. To overcome the limitations associated with studying the rare B cells that give rise to these responses, we generated a mouse in which the rearranged heavy chain variable region from a tumor glycan-reactive antibody was knocked into the endogenous heavy chain locus. We propose to characterize this mouse model by determining the potential for transgenic B cells to carry out antibody-dependent versus antibody-independent effector mechanisms in the productive anti-tumor response (Aim 1) and identify conditions which stimulate transgenic B cells to undergo isotype switching and differentiation to plasma cells (Aim 2). The findings emanating from these studies are expected to reveal novel strategies to harness the anti-tumor potential of B cells with specificities for cancer-expressed glycans.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $169,329 )
2025	2025	WAKE FOREST UNIVERSITY HEALTH SCIENCES	MEDICAL CENTER BLVD	WINSTON SALEM	NC	27157	FORSYTH	USA	Cancer Treatment Research	000	1	11/28/2024	NEW	$169,329
														Subtotal = $169,329

Grand Total All Awards = $169,329

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A BCR transgenic mouse model to study glycan-specific B cells

Award Number: R21CA297692

ORGANIZATION: NATIONAL CANCER INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 02/01/2025

PERIOD OF PERFORMANCE END DATE: 01/31/2027

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