Saturday, August 2, 2025 8/2/2025

Sequential infection of laboratory mice for enhanced cancer and immunotherapy translation

Award Number: R21CA296062
ORGANIZATION: NATIONAL CANCER INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 08/01/2025
PERIOD OF PERFORMANCE END DATE: 07/31/2027

Group Awards By:

View Award Description

Sequential infection of laboratory mice for enhanced cancer and immunotherapy translation - ABSTRACT Mouse models have been tremendously important to understand and develop treatments for humans. Yet, from an immune perspective, mouse models resemble an immature immune system, including lack of microbiota adaptations, infections, and vaccinations that humans encounter early in life to shape immune maturation. Use of wild-caught mice that have a more adult-like immune system has helped to better understand the adult immune response; however, these mice have a series of practical and genetic issues that preclude their widespread use. We hypothesize that the neonatal like immune system in Specific Pathogen Free (SPF) mice that are normally used in the laboratory underlies many of the differences observed between mouse and human anti-tumor responses and the translatability of therapeutic approaches. To overcome this, we will adapt and develop a strategy to produce lab-generated “wild-like” mice that mimic the immune response observed in adults. We propose that these lab-generated “wild-like” mice will recapitulate the adult human immune system and mimic the responses to cancer and immunotherapy observed in humans. This approach of immune education is performed on otherwise wild-type mice, enabling wide-spread adoption to foster cancer studies.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $138,846 )
2025	2025	UNIVERSITY HEALTH NETWORK	200 ELIZABETH ST	TORONTO	ON			CAN	Cancer Detection and Diagnosis Research	000	1	7/23/2025	NEW	$138,846
														Subtotal = $138,846

Grand Total All Awards = $138,846

Top

All Categories

About

Search

Reports

Data Submission

Award Information

Sequential infection of laboratory mice for enhanced cancer and immunotherapy translation

Award Number: R21CA296062

ORGANIZATION: NATIONAL CANCER INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 08/01/2025

PERIOD OF PERFORMANCE END DATE: 07/31/2027

Federal Websites

Department of Health & Human Services

HHS Operating Divisions

HHS Staff Divisions

Download A Document Viewer