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Development of integrated risk models of genetic and non-genetic risk factors in endometrial cancer across diverse ancestries

Award Number: R21CA294233
ORGANIZATION: NATIONAL CANCER INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/02/2024
PERIOD OF PERFORMANCE END DATE: 08/31/2026

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Development of integrated risk models of genetic and non-genetic risk factors in endometrial cancer across diverse ancestries - PROJECT SUMMARY The incidence of Endometrial Cancer (EC) has been rising, with a notable increase in mortality rates, especially among Black women who face a higher risk of aggressive EC subtypes. Current diagnostic methods for EC are invasive, costly, and typically utilized in advanced stages of the disease, highlighting a critical need for early detection techniques. This project aims to enhance early EC detection and understand the complex interplay of genetic, social, and environmental factors contributing to EC risk, with a focus on addressing disparities in EC outcomes among different racial and ethnic groups. In the proposed research, we aim to determine the burden of rare germline pathogenic variation associated with endometrial cancer risk in racially and ethnically diverse case control cohorts utilizing the All of USs biobank datasets. This approach will provide new insights into the genetic factors influencing EC, especially in underrepresented populations. We will create advanced risk models that integrate a wide array of risk factors, including genetic predispositions and lifestyle factors, into comprehensive predictive models, combining genetic data with non-genetic factors (e.g., BMI, diabetes history, PCOS) and validated across different racial and ethnic subgroups, offering a personalized risk assessment tool for EC. The successful completion of this project will yield a comprehensive understanding of the genetic and non-genetic factors contributing to EC risk, particularly in racial and ethnic groups that have been historically understudied. The development of integrated risk models will facilitate early detection of EC, leading to timely interventions and potentially better survival rates. This project has the potential to revolutionize EC screening and prevention strategies, making them more effective and accessible across diverse populations, thereby addressing a significant public health concern. .


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $456,103 )
2024	2024	THE FEINSTEIN INSTITUTES FOR MEDICAL RESEARCH	350 COMMUNITY DR	MANHASSET	NY	11030	NASSAU	USA	Cancer Biology Research	000	1	9/2/2024	NEW	$456,103
														Subtotal = $456,103

Grand Total All Awards = $456,103

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Development of integrated risk models of genetic and non-genetic risk factors in endometrial cancer across diverse ancestries

Award Number: R21CA294233

ORGANIZATION: NATIONAL CANCER INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/02/2024

PERIOD OF PERFORMANCE END DATE: 08/31/2026

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