Thursday, September 18, 2025 9/18/2025

The Role of Platelets in Cancer Cachexia

Award Number: R21CA289464
ORGANIZATION: NATIONAL CANCER INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 03/05/2024
PERIOD OF PERFORMANCE END DATE: 02/28/2026

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The Role of Platelets in Cancer Cachexia - SUMMARY Cancer cachexia is a complex metabolic syndrome characterized by muscle wasting, weight loss, and decreased quality of life. Patients with cancer cachexia experience impaired muscle function, reduced treatment tolerance, and lower survival rates. Despite progress in understanding the condition, its underlying mechanism and high mortality rate remain unclear. The proposed research aims to investigate the role of platelets in cancer cachexia development, as they are involved in inflammation and tissue wasting. Preliminary data suggest an association between elevated platelet counts and the pre-cachexia stage and platelet activation and severe/refractory cachexia. The proposed study hypothesizes that platelets play a crucial role in the recruitment of immune cells and the release of pro-cachectic factors, ultimately leading to muscle loss. The research will test the hypothesis through two aims: depleting platelets at pre-cachectic stages to assess the impact on inflammation and muscle wasting and examining the effects of activated platelets on muscle wasting in cancer and chemotherapy-induced cachexia. The project aims to provide novel insights and potential approaches by targeting platelets in cancer cachexia.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $169,439 )
2025	2025	UNIVERSITY OF SOUTH CAROLINA	1600 HAMPTON ST	COLUMBIA	SC	29208	RICHLAND	USA	Cancer Biology Research	001	2	9/9/2025	NON-COMPETING CONTINUATION	$16,943
2025	2025	UNIVERSITY OF SOUTH CAROLINA	1600 HAMPTON ST	COLUMBIA	SC	29208	RICHLAND	USA	Cancer Biology Research	000	2	2/12/2025	NON-COMPETING CONTINUATION	$152,496
														Subtotal = $169,439

Issue Date FY: 2024 ( Subtotal = $204,391 )
2024	2024	UNIVERSITY OF SOUTH CAROLINA	1600 HAMPTON ST	COLUMBIA	SC	29208	RICHLAND	USA	Cancer Biology Research	000	1	3/5/2024	NEW	$204,391
														Subtotal = $204,391

Grand Total All Awards = $373,830

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The Role of Platelets in Cancer Cachexia

Award Number: R21CA289464

ORGANIZATION: NATIONAL CANCER INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 03/05/2024

PERIOD OF PERFORMANCE END DATE: 02/28/2026

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