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Novel Immunotherapy Targeting Local and Systemic Immunity for Treatment of Ocular Surface Squamous Neoplasia

Award Number: R21CA289152
ORGANIZATION: NATIONAL CANCER INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 04/10/2025
PERIOD OF PERFORMANCE END DATE: 03/31/2027

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Novel Immunotherapy Targeting Local and Systemic Immunity for Treatment of Ocular Surface Squamous Neoplasia - Project Summary Ocular surface squamous neoplasia (OSSN) is a progressive ocular cancer that lacks approved treatments and is increasing in prevalence globally. We have developed a new liposomal-TLR agonist immunotherapy (LTAC) that in a novel equine spontaneous OSSN model effectively induces OSSN resolution following topical and perilesional administration in most treated animals. We now propose to use the equine OSSN model to elucidate immunological mechanisms underlying the antitumor activity of LTAC immunotherapy. In Aim 1, local immune responses will be investigated using tumor biopsy and corneal swab samples, including immunohistochemistry and transcriptomic analysis. These studies will identify immune correlates with responsiveness and resistance to immunotherapy. In Aim 2 we will determine whether LTAC immunotherapy also induces systemic immunity to OSSN, using OSSN antigen-specific T cell and antibody assays. These studies overall will advance the field of ocular immunotherapy for ocular cancers and provide important new insights into local and systemic OSSN immunity.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $215,985 )
2025	2025	COLORADO STATE UNIVERSITY	601 S HOWES ST	FORT COLLINS	CO	80521	LARIMER	USA	Cancer Treatment Research	000	1	4/7/2025	NEW	$215,985
														Subtotal = $215,985

Grand Total All Awards = $215,985

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Novel Immunotherapy Targeting Local and Systemic Immunity for Treatment of Ocular Surface Squamous Neoplasia

Award Number: R21CA289152

ORGANIZATION: NATIONAL CANCER INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 04/10/2025

PERIOD OF PERFORMANCE END DATE: 03/31/2027

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