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Informing Cancer Epidemiology Through the Identification of Differentiating Chemical Constituents of Cigarillo Smoke

Award Number: R21CA263809
ORGANIZATION: NATIONAL CANCER INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/16/2021
PERIOD OF PERFORMANCE END DATE: 09/30/2023

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Informing Cancer Epidemiology Through the Identification of Differentiating Chemical Constituents of Cigarillo Smoke - Project Summary Cigar smoking is associated with multiple negative health outcomes, including increased risks for various types of cancer. Cigar use in the U.S. increased between 2000 and 2011 even as cigarette sales declined over the same time period. Cigar use is common among minority youth and as a vehicle to administer cannabis. Within the product class of cigars, cigarillos are the most commonly used in the U.S. and are associated with specific public health concerns, including higher rates of use by young adults (ages 18–24) in contrast to older adults and different patterns of co-use of multiple tobacco products. Thus, it is important to improve the understanding of particular factors related to cigarillo use in order to inform cancer epidemiology. In the proposed research, we will identify the chemical constituents of mainstream cigarillo smoke that are different than those of mainstream cigarette smoke through non-targeted chemical analysis (i.e., the identification of chemicals that are not specified prior to analyzing a given sample). The expected results are important for epidemiological purposes in that they can reveal carcinogens in cigarillo smoke beyond those known to be commonly associated with tobacco smoke in general, thus providing a better understanding of environmental risk factors in epidemiological research. Furthermore, the identified compounds can be used in later research projects to inform the development of biomarkers of exposure that can be used in individual or population base sampling to estimate cigarillo exposure. To achieve our research objective, we will employ two-dimensional gas chromatography–time-of-flight mass spectrometry (GC×GC-TOFMS), an advanced analytical chemistry technique with powerful capabilities for non-targeted chemical analysis. GC×GC-TOFMS will be used to collect non-targeted analytical chemistry data for both cigarillo smoke and cigarette smoke. The data from the two product (sub)classes will be compared against one another, and those signals that differentiate the product (sub)classes will be assessed using computational toxicology databases (e.g., the Environmental Protection Agency CompTox Chemicals Dashboard) to determine which are most likely from compounds that would present significant carcinogenicity concerns in cigarillo smoke. Additional analyses will then be performed using authentic chemical standards to confirm the chemical identities and to quantify the amounts in both cigarillo smoke and cigarette smoke. The proposed innovative research is designed to identify and quantify specific chemical constituents (1) that differentiate cigarillo smoke from cigarette smoke, and (2) that are potentially carcinogenic. The results will complement epidemiological data regarding the impact to public health associated with cigarillo use. This investigation will thus advance cancer research through expanding knowledge about cancer risks for those populations most affected by cigarillo smoking.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $0 )
2024	2021	BATTELLE MEMORIAL INSTITUTE	505 KING AVE	COLUMBUS	OH	43201	FRANKLIN	USA	Cancer Cause and Prevention Research	000	1	4/5/2024	NEW	$0
														Subtotal = $0

Issue Date FY: 2023 ( Subtotal = $0 )
2023	2021	BATTELLE MEMORIAL INSTITUTE	505 KING AVE	COLUMBUS	OH	43201	FRANKLIN	USA	Cancer Cause and Prevention Research	000	1	9/19/2023	NEW	$0
														Subtotal = $0

Issue Date FY: 2021 ( Subtotal = $409,936 )
2021	2021	BATTELLE MEMORIAL INSTITUTE	505 KING AVE	COLUMBUS	OH	43201	FRANKLIN	USA	Cancer Cause and Prevention Research	000	1	9/16/2021	NEW	$409,936
														Subtotal = $409,936

Grand Total All Awards = $409,936

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Informing Cancer Epidemiology Through the Identification of Differentiating Chemical Constituents of Cigarillo Smoke

Award Number: R21CA263809

ORGANIZATION: NATIONAL CANCER INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/16/2021

PERIOD OF PERFORMANCE END DATE: 09/30/2023

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