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Using the Collaborative Cross for Model Studies of Intestinal Cancer

Award Number: R21CA202496
ORGANIZATION: NATIONAL CANCER INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 07/01/2016
PERIOD OF PERFORMANCE END DATE: 12/31/2019

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Using the Collaborative Cross for Model Studies of Intestinal Cancer - DESCRIPTION (provided by applicant: Gastrointestinal (GI) cancers are worldwide health issues that are both highly prevalent and deadly. The ability to understand the genetic factors influencing the change of normal stomach, small intestine and colorectal tissues towards the initiation, growth and progression to cancer is essential to the goals of precision medicine. As with every cancer, being able to identify people at risk before the cancer appears provides the greatest opportunity to intervene and prevent the development of life-threatening disease. To better model human disease, the Collaborative Cross (CC) was generated and has captured the tremendous genomic variation present within one mammalian species, the mouse. The CC are recombinant inbred (RI) lines created from the genomic contributions of 8 inbred founder strains, chosen because of their evolutionary diversity with each other. The unique combination of alleles within the different CC lines facilitates 1) the identification of phenotypes more extree than have been observed in common inbred laboratory strains, and 2) the opportunity for high resolution mapping of loci influencing complex traits. Our studies represent an avenue to investigate GI tumor phenotypes governed by allelic variation. We propose to use a sensitized background, namely a mutation in the adenomatous polyposis coli (Apc) gene coupled with a resistant Mom2R allele, and mate these mice with the CC lines in a one-step cross to screen for dominant modifiers that lead to increased tumorigenesis or altered tumor profiles. We have incorporated a mutant Apc allele because the APC gene is one of the top 5 genes mutated in all 3 GI cancers in humans. The use of the CC lines coupled with the use of our unique, long-lived, but sensitized congenic strain background provides an innovative approach to the study of GI cancers.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2020 ( Subtotal = -$2,496 )
2020	2017	SETON HALL UNIVERSITY	400 S ORANGE AVE	SOUTH ORANGE	NJ	07079	ESSEX	USA	Cancer Cause and Prevention Research	000	3	7/29/2020	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	-$2,496
														Subtotal = -$2,496

Issue Date FY: 2019 ( Subtotal = $0 )
2019	2017	SETON HALL UNIVERSITY	400 S ORANGE AVE	SOUTH ORANGE	NJ	07079	ESSEX	USA	Cancer Cause and Prevention Research	001	3	11/1/2018	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$3,121
2019	2017	THOMAS JEFFERSON UNIVERSITY	1020 WALNUT ST STE 1	PHILADELPHIA	PA	19107	PHILADELPHIA	USA	Cancer Cause and Prevention Research	000	2	11/1/2018	NON-COMPETING CONTINUATION	-$3,121
2019	2017	SETON HALL UNIVERSITY	400 S ORANGE AVE	SOUTH ORANGE	NJ	07079	ESSEX	USA	Cancer Cause and Prevention Research	002	3	2/7/2019	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$0
														Subtotal = $0

Issue Date FY: 2018 ( Subtotal = $0 )
2018	2017	SETON HALL UNIVERSITY	400 S ORANGE AVE	SOUTH ORANGE	NJ	07079	ESSEX	USA	Cancer Cause and Prevention Research	001	3	9/18/2018	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$20,531
2018	2017	THOMAS JEFFERSON UNIVERSITY	1020 WALNUT ST STE 1	PHILADELPHIA	PA	19107	PHILADELPHIA	USA	Cancer Cause and Prevention Research	000	2	9/17/2018	NON-COMPETING CONTINUATION	-$20,531
														Subtotal = $0

Issue Date FY: 2017 ( Subtotal = $169,650 )
2017	2017	THOMAS JEFFERSON UNIVERSITY	1020 WALNUT ST STE 1	PHILADELPHIA	PA	19107	PHILADELPHIA	USA	Cancer Cause and Prevention Research	000	2	6/28/2017	NON-COMPETING CONTINUATION	$169,650
														Subtotal = $169,650

Issue Date FY: 2016 ( Subtotal = $203,580 )
2016	2016	THOMAS JEFFERSON UNIVERSITY	1020 WALNUT ST	PHILADELPHIA	PA	19107	PHILADELPHIA	USA	Cancer Cause and Prevention Research	000	1	7/1/2016	NEW	$203,580
														Subtotal = $203,580

Grand Total All Awards = $370,734

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Using the Collaborative Cross for Model Studies of Intestinal Cancer

Award Number: R21CA202496

ORGANIZATION: NATIONAL CANCER INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 07/01/2016

PERIOD OF PERFORMANCE END DATE: 12/31/2019

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