Friday, June 20, 2025 6/20/2025

Identification and annotation of 3' UTR ends using RNA-seq data

Award Number: R21CA187910
ORGANIZATION: NATIONAL CANCER INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/17/2014
PERIOD OF PERFORMANCE END DATE: 08/31/2016

Group Awards By:

View Award Description

Identification and annotation of 3' UTR ends using RNA-seq data - DESCRIPTION (provided by applicant): When a gene is activated, it is copied ("transcribed") from DNA into a string of molecules called a messenger RNA (mRNA). The middle section of each mRNA encodes the information that is translated into the corresponding protein sequence; the two ends, called untranslated regions (UTRs), play a number of other important roles. This proposal concerns the tail end of the mRNA, known as the 3' UTR, which helps to regulate the stability and location of the mRNA and the amount of the corresponding protein that is produced. The point at which the transcription of a given mRNA ends is determined by the presence of a sequence called a polyadenylation site. Some genes have more than one such site, meaning that there can be two or more different forms of the corresponding mRNA, with different 3' UTRs and therefore different levels of activity. Changes in the ratio of the different forms are thought to contribute to the development of a range of disorders, including some cancers. The methods currently used to study polyadenylation require an extra set of experiments to be run, which is expensive and slow. However, Drs. Birol and Karsan and their teams have obtained evidence that polyadenylation can be studied alongside other important types of transcriptional regulation, using data from experiments that are already performed as part of standard analysis. This will make studies of polyadenylation sites affordable by more laboratories, and will add value to existing data.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2017 ( Subtotal = $0 )
2017	2015	BRITISH COLUMBIA CANCER AGENCY BRANCH	600 10TH AVE W	VANCOUVER	BC	V5Z 4E6		CAN	Cancer Biology Research	000	2	12/9/2016	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2016 ( Subtotal = $43,179 )
2016	2016	BRITISH COLUMBIA CANCER AGENCY	600 West 10th Avenue	VANCOUVER				CAN	Cancer Cause and Prevention Research	000	2	1/8/2016	SUPPLEMENT FOR EXPANSION	$43,179
														Subtotal = $43,179

Issue Date FY: 2015 ( Subtotal = $101,050 )
2015	2015	BRITISH COLUMBIA CANCER AGENCY	600 West 10th Avenue	VANCOUVER				CAN	Cancer Biology Research	000	2	7/23/2015	NON-COMPETING CONTINUATION	$101,050
														Subtotal = $101,050

Issue Date FY: 2014 ( Subtotal = $103,360 )
2014	2014	BRITISH COLUMBIA CANCER AGENCY	600 West 10th Avenue	VANCOUVER				CAN	Cancer Biology Research	000	1	9/17/2014	NEW	$103,360
														Subtotal = $103,360

Grand Total All Awards = $247,589

Top

All Categories

About

Search

Reports

Data Submission

Award Information

Identification and annotation of 3' UTR ends using RNA-seq data

Award Number: R21CA187910

ORGANIZATION: NATIONAL CANCER INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/17/2014

PERIOD OF PERFORMANCE END DATE: 08/31/2016

Federal Websites

Department of Health & Human Services

HHS Operating Divisions

HHS Staff Divisions

Download A Document Viewer