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TARGETING NOTCH AND TYROSINE KINASE RECEPTORS IN KS

Award Number: R21CA108450
ORGANIZATION: NATIONAL CANCER INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 04/07/2004
PERIOD OF PERFORMANCE END DATE: 03/31/2006

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TARGETING NOTCH AND TYROSINE KINASE RECEPTORS IN KS - DESCRIPTION (provided by applicant): Kaposi's sarcoma (KS) is the most common neoplasm in AIDS patients and is responsible for significant morbidity and mortality worldwide. There is no cure for KS, and current treatments are only able to temporarily relieve its symptoms. As part of our ongoing studies to understand the complex pathogenesis of KS, we have recently begun experiments examining Notch receptor activity in this neoplasm. Notch receptors are an evolutionarily conserved family of transmembrane receptors known to play a fundamental role in cell fate decisions including cell proliferation, differentiation and apoptosis. It is therefore not surprising that deregulated expression of Notch receptors, ligands, and/or target proteins has been associated with tumorigenesis in several cell systems. We hypothesize that deregulated Notch signaling contributes to the survival and proliferation of KS tumor cells, and Notch inactivation is a potential therapeutic strategy for KS. In this application, we propose to systematically examine Notch activity in KS tumor cells in vitro and in vivo. The studies will then be expanded to examine the biologic significance of Notch inhibition in in vitro and in vivo models of KS, including the human skin-SCID mouse model. Completion of these studies will provide new information on Notch expression and activity in KS and will determine if Notch is an appropriate target for developing new therapeutic approaches for this potentially life-threatening neoplasm.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2005 ( Subtotal = $199,800 )
2005	2005	LOYOLA UNIVERSITY MEDICAL CENTER							Cancer Cause and Prevention Research	000	2	3/3/2005	NON-COMPETING CONTINUATION	$199,800
														Subtotal = $199,800

Issue Date FY: 2004 ( Subtotal = $166,500 )
2004	2004	LOYOLA UNIVERSITY MEDICAL CENTER							Cancer Cause and Prevention Research	000	1	4/7/2004	NEW	$166,500
														Subtotal = $166,500

Grand Total All Awards = $366,300

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TARGETING NOTCH AND TYROSINE KINASE RECEPTORS IN KS

Award Number: R21CA108450

ORGANIZATION: NATIONAL CANCER INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 04/07/2004

PERIOD OF PERFORMANCE END DATE: 03/31/2006

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